Skip to main content
SpringerLink
Log in

Blue rubber-bled naevus syndrome: Report of a case with consumption coagulopathy complicated by manifest thrombosis

  • Dermatology
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Blue rubber-bleb naevus (BRBN) syndrome is a rare disorder characterized by subcutaneous and gastrointestinal haemangiomas. The latter may lead to bleeding complications. A case is reported in which a process of chronic intravascular coagulation resulted in serious thrombotic complications. In the presence of a chronic consumption coagulopathy, it remains uncertain whether antiplatelet drugs are of prophylactic antithrombotic value.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

BRBN:

Blue rubber-bled naevus syndrome

References

  1. Bartoshesky LE, Bull M, Feingold M (1978) Corticosteroid treatment of cutaneous hemangiomas: how effective?: a report on 24 children. Clin Pediatr 17:625–638

    Google Scholar 

  2. Bean WB (1958) Vasular spiders and related lesions of the skin. Thomas, Springfield, pp 178–185

    Google Scholar 

  3. Carnelli V, Bellini F, Ferrari M, Rossi E, Masera G (1977) Giant hemangioma with consumption coagulopathy: sustained response to heparin and radiotherapy. J Pediatr 91:504–505

    Google Scholar 

  4. Fretzin DF, Potter B (1965) Blue rubber-bled nevus. Arch Intern Med 116:924–929

    Google Scholar 

  5. Gilardi S, Harms M (1982) Genetische Aspekte des Blue Rubber Bled Nävussyndroms und der multiplen gegeneralisierten Glomangiomatose. Hautarzt 33:96–100

    Google Scholar 

  6. Kasabach HH, Merritt KK (1940) Capillary hemangioma with extensive purpura: report of a case. Am J Dis Child 59:1063–1070

    Google Scholar 

  7. Koerper MA, Addiego JE, Lorimier AA de, Lipow H, Price D, Lubin BH (1983) Use of aspirin and dipyramidole in children with platelet trapping syndromes. J Pediatr 102:311–314

    Google Scholar 

  8. Oranje AP (1986) Blue Rubber Bleb Nevus Syndrome. Pediatr Dermatol 3:304–310

    Google Scholar 

  9. Sondel PM, Ritter MW, Wilson DG, Lieberman LM (1984) Use of111In platelet scans in the detection and treatment of Kasabach-Merritt syndrome. J Pediatr 104:87–89

    Google Scholar 

  10. Warrell RP, Kempin SJ (1985) Treatment of severe coagulopathy in the Kasabach-Merritt syndrome with aminocaproic acid and cryoprecipitate. N Engl J Med 313:309–312

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Paediatrics, Division of Haematology-Oncology, Erasmus University and University Hospital Rotterdam/Sophia Children's Hospital, Gordelweg 160, 3038 GE, Rotterdam, The Netherlands

    W. J. D. Hofhuis

  2. Department of Dermatology and Venereology, Division of Paediatric Dermatology, Erasmus University and University Hospital Rotterdam/Sophia Children's Hospital, Gordelweg 160, 3038 GE, Rotterdam, The Netherlands

    A. P. Oranje

  3. Department of Paediatrics, Division of Gastro-enterology, Erasmus University and University Hospital Rotterdam/Sophia Children's Hospital, Gordelweg 160, 3038 GE, Rotterdam, The Netherlands

    J. Bouquet & M. Sinaasappel

Authors
  1. W. J. D. Hofhuis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. P. Oranje
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Bouquet
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Sinaasappel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hofhuis, W.J.D., Oranje, A.P., Bouquet, J. et al. Blue rubber-bled naevus syndrome: Report of a case with consumption coagulopathy complicated by manifest thrombosis. Eur J Pediatr 149, 526–528 (1990). https://doi.org/10.1007/BF01957684

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01957684

Key words

Search

Navigation