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Clinical use of the long acting somatostatin analogue octreotide in pediatrics

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Abstract

Preliminary data of the use of the long-acting somatostatin analog octreotide (Sandostatin) in pediatrics are reported. In nesidioblastosis and other hyperinsulinemic conditions, timely treatment with octreotide can protect cerebral function and may reduce mortality. The acure use of octreotide produces prompt elevation of blood glucose, even in patients who fail to respond to diazoxide. In addition, it may be possible to avoid the need for partial or subtotal pancreatectomy by the long-term use of octreotide. As in adults, octreotide should find a place in the symptomatic treatment of secretory diarrhea, notably the watery diarrheahypokalemia-achlorhydria complex and pancreatic cholera syndrome. Octreotide has been shown to be effective in the treatment of familial tall stature by reducing height velocity and final height. Responses to octreotide therapy vary and the individual responsiveness must be extensively studied.

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Abbreviations

GH :

growth hormone

WDHA :

watery diarrhea hypokalemia achlorhydria

VIP :

vasoactive intestinal polypeptide

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Authors and Affiliations

  1. Department of Paediatric Endocrinology, CHU Purpan, F-31059, Pavillon Leriche, Toulouse, France

    M. T. Tauber & P. Rochiccioli

  2. Division of Clinical Pharmacology Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd., 90048, Los Angeles, CA, USA

    A. G. Harris

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  1. M. T. Tauber
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  2. A. G. Harris
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  3. P. Rochiccioli
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Tauber, M.T., Harris, A.G. & Rochiccioli, P. Clinical use of the long acting somatostatin analogue octreotide in pediatrics. Eur J Pediatr 153, 304–310 (1994). https://doi.org/10.1007/BF01956407

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