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Chronic cadmium intake results in dose-related excretion of metallothionein in urine

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Summary

Urinary excretion of metallothionein was measured by radioimmunoassay in rats given drinking water containing 5 or 50 mg cadmium/1 for up to 2 years. The metallothionein levels corresponded to the concentration of cadmium in the drinking water and increased linearly over the course of the study. These results demonstrate that urinary metallothionein is a sensitive biological indicator of oral cadmium exposure.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Rhode Island, 02881, Kingston, Rhode Island, USA

    Z. A. Shaikh & K. M. Harnett

  2. Department of Environmental Health Sciences, Johns Hopkins University, 21205, Baltimore, Maryland, USA

    S. A. Perlin

  3. Department of Biochemistry, Johns Hopkins University, 21205, Baltimore, Maryland, USA

    P. C. Huang

Authors
  1. Z. A. Shaikh
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  2. K. M. Harnett
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  3. S. A. Perlin
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  4. P. C. Huang
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Shaikh, Z.A., Harnett, K.M., Perlin, S.A. et al. Chronic cadmium intake results in dose-related excretion of metallothionein in urine. Experientia 45, 146–148 (1989). https://doi.org/10.1007/BF01954852

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  • DOI: https://doi.org/10.1007/BF01954852

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