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Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis

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Summary

The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.

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Author notes

  1. G. A. Turner

    Present address: Department Experimental Pathology, Roswell Park Memorial Institute, 666 Elm Street, 14263, Buffalo, (New York, USA

Authors and Affiliations

  1. Royal Victoria Infirmary, University Department of Clinical Biochemistry, NE1 4LP, Newcastle upon Tyne, England

    G. A. Turner

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  1. G. A. Turner
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Turner, G.A. Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis. Experientia 35, 1657–1658 (1979). https://doi.org/10.1007/BF01953252

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  • DOI: https://doi.org/10.1007/BF01953252

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