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Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxide-induced microsomal lipid peroxidation

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  • Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology
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Summary

We have observed a differential effect of silybin dihemisuccinate on rat liver microsonal oxygen consumption and on lipid peroxidation induced by NADPH-Fe2+-ADP and t-butyl hydroperoxide. These results are ascribed to the antioxidant properties of the flavonoid. The differences observed in the effect of the catalysts may be a consequence of the different capacity of silybin to act as a scavenger of free radicals formed by NADPH-Fe2+-ADP or t-butyl hydroperoxide.

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Authors and Affiliations

  1. Laboratorio Bioquímica, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Casilla 15138, Santiago 11, Chile

    A. Valenzuela & R. Guerra

Authors
  1. A. Valenzuela
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  2. R. Guerra
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This research was supported in part by grant B-2019-8412 from Dirección de Investigación y Bibliotecas, Universidad de Chile.

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Valenzuela, A., Guerra, R. Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxide-induced microsomal lipid peroxidation. Experientia 42, 139–141 (1986). https://doi.org/10.1007/BF01952435

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  • DOI: https://doi.org/10.1007/BF01952435

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