Summary
Experiments with permeabilised platelets, and with intact platelets loaded with fluorescent Ca2+-indicators, over the past several years have greatly extended our knowledge and understanding of cytosolic Ca2+ as a platelet activator and its interactions with other cytosolic regulators. This article outlines insights, gained from the use of the fluorescent dyes, into maintenance and restoration of basal [Ca2+]i, mechanisms of receptor-mediated Ca2+-mobilisation and quantitation of [Ca2+]i/response relations in intact human platelets.
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Rink, T.J. Cytosolic calcium in platelet activation. Experientia 44, 97–100 (1988). https://doi.org/10.1007/BF01952188
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DOI: https://doi.org/10.1007/BF01952188