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The effect of nicotine on blood pressure in the genetically hypertensive mouse

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Summary

Mice genetically selected for high and low blood pressure were exposed to nicotine via a single injected dose or addition to drinking water for 52 weeks. In the acute study, the response of mice with high blood pressure was a statistically significant increase in blood pressure. In the chronic study the pattern of response to nicotine ingestion was similar for mice with high blood pressure and those with low. Both lines responded with an increase in blood pressure after 6 weeks followed by a decrease to below baseline blood pressure at 12 weeks.

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Authors and Affiliations

  1. Division of Biological Sciences, University of Kansas, Snow Hall, 66045-2106, Lawrence, Kansas, USA

    L. C. Backer & G. Schlager

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  1. L. C. Backer
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  2. G. Schlager
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This research was supported in part by an allocation from the General Research Fund of the University of Kansas.

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Backer, L.C., Schlager, G. The effect of nicotine on blood pressure in the genetically hypertensive mouse. Experientia 40, 1363–1364 (1984). https://doi.org/10.1007/BF01951890

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