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Annonacin, a novel, biologically active polyketide fromAnnona densicoma

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Summary

A new linear polyketide, Annonacin (I), has been isolated from active extracts of the stembark ofAnnona densicoma Mart. Annonacin (I) is highly cytotoxic and is active in an assay designed to detect antimitotic agents. The structure of (I) was determined by analysis of spectroscopic data.

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Authors and Affiliations

  1. Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 47907, West Lafayette, Indiana, USA

    T. G. McCloud, D. L. Smith, C. -J. Chang & J. M. Cassady

Authors
  1. T. G. McCloud
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  2. D. L. Smith
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  3. C. -J. Chang
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  4. J. M. Cassady
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25 September 1986

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McCloud, T.G., Smith, D.L., Chang, C.J. et al. Annonacin, a novel, biologically active polyketide fromAnnona densicoma. Experientia 43, 947–949 (1987). https://doi.org/10.1007/BF01951681

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  • DOI: https://doi.org/10.1007/BF01951681

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