Skip to main content
SpringerLink
Log in

Platelet aggregation by Thrombofax®. Studies on the mechanism of action

  • Published:
Experientia Aims and scope Submit manuscript

Résumé

Le Thrombofax Ortho provoque l'agrégation des plaquettes humaines (ainsi que celles du chien, du cobaye et du rat) suite à la libération d'ADP endoplaquettaire. La14C-sérotonine et le facteur plaquettaire 4 sont aussi libérés au cours de la réaction. La fraction active du produit semble résider dans les acides gras libres.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. G. de Gaetano, A. Vandenbussche andJ. Vermylen, Experientia28, 1127 (1972).

    Article  PubMed  Google Scholar 

  2. B. Baker, personal communication (1969).

  3. F. Declerck, personal communication (1971).

  4. G. de Gaetano, D. Bottecchia andJ. Vermylen, Thrombosis Res.2, 71 (1973).

    Article  Google Scholar 

  5. E. D. Warner, J. C. Hoak andW. C. Connor, inPlatelets: Their Role in Hemostasis and Thrombosis (Schattauer, Stuttgart 1967), p. 249.

    Google Scholar 

  6. C. M. van Gent, personal communication (1969).

  7. P. A. Shore andH. S. Alpers, Nature, Lond.200, 1331 (1963).

    Google Scholar 

  8. R. J. Haslam, Nature, Lond.202, 765 (1964).

    Google Scholar 

  9. J. W. Kerr, P. Pirrie, J. Macaulay andB. Bronte-Stewart, Lancet1, 1296 (1965).

    Article  Google Scholar 

  10. H. J. Weiss andJ. Rogers, Blood39, 187 (1972).

    PubMed  Google Scholar 

  11. G. de Gaetano, M. B. Donati andJ. Vermylen, Int. J. clin. Pharmac.5, 196 (1971).

    Google Scholar 

  12. G. de Gaetano, M. Casteels-Van Daele, J. H. Claes andR. Eeckels, Helv. paediat. Acta26, 423 (1971).

    PubMed  Google Scholar 

  13. K. Harada andM. B. Zucker Thromb. Diath. haemorrh.25, 41 (1971).

    PubMed  Google Scholar 

  14. M. B. Donati, M. Palester-Chlebowczyk, G. de Gaetano andJ. Vermylen, Adv. expt. Med. Biol.34, 295 (1972).

    Google Scholar 

  15. The experienced technical assistance of MissA. Vandenbussche is gratefully acknowledged.

Download references

Author information

Author notes

  1. G. de Gaetano (Fellow of the Katholieke Universiteit te Leuven, 1972/73)

    Present address: Laboratory for Haemostasis and Thrombosis Research, Mario Negri Institute, V. Eritrea, 62, I-20157, Milano, (Italy)

Authors and Affiliations

  1. Laboratory of Blood Coagulation, Medical Research Department, University of Leuven, Leuven, (Belgium)

    G. de Gaetano (Fellow of the Katholieke Universiteit te Leuven, 1972/73), J. Vermylen & M. Verstraete

Authors
  1. G. de Gaetano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Vermylen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Verstraete
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by grant No. 1216 of the Fonds voor Geneeskundig Wetenschappelijk Onderzoek, Brussels.

Rights and permissions

Reprints and permissions

About this article

Cite this article

de Gaetano, G., Vermylen, J. & Verstraete, M. Platelet aggregation by Thrombofax®. Studies on the mechanism of action. Experientia 29, 1136–1137 (1973). https://doi.org/10.1007/BF01946766

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01946766

Keywords

Search

Navigation