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Correlation of physicochemical parameters and biological activity in steroids 9α-substituted cortisol derivatives

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Resumen

Por primera vez se han analizado las relaciones estructura-función de diez derivados del 9α-cortisol substituido usando técnicas de regresión de parámetros múltiples. Se concluye que los factores electrónicos y estéricos son de mayor importancia al determinar el efecto del substituyente, y que la unión hidrofóbica también es de importante consideración. Se discute el significado de estos resultados.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, 94122, San Fransisco, California, USA

    M. E. Wolff & C. Hansch

  2. Department of Chemistry, Pomona College, 91713, Claremont, California, USA

    M. E. Wolff & C. Hansch

Authors
  1. M. E. Wolff
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  2. C. Hansch
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Additional information

This investigation was supported in part by Public Health Service Research Grants No. AM-14824 (to M.E.W.) and No. GM 07492 (to C.H.) from the National Institutes of Arthritis and Metabolic Diseases, and General Medical Sciences, U.S. Public Health Service.

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Wolff, M.E., Hansch, C. Correlation of physicochemical parameters and biological activity in steroids 9α-substituted cortisol derivatives. Experientia 29, 1111–1113 (1973). https://doi.org/10.1007/BF01946750

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