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Inhibition of phosphodiesteras by dihydroergotamine and hydergine in various organs of the cat in vitro

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Zusammenfassung

Die Hemmung der cAMP-Phosphodiesterase in verschiedenen Organen der Katze durch Hydergin und DHE wurde in vitro bestimmt. In Konzentrationen von 10−4 M bis 10−6 M wurde ein Hemmeffekt nur im Gehirn beobachtet. Diese Wirkung wird besonders deutlich, wenn man das infolge der Enzymhemmung nicht umgesetzte cAMP berechnet.

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Authors and Affiliations

  1. Medical Basic Research, Sandoz Ltd., CH-4002, Basel, (Switzerland)

    P. Iwangoff & A. Enz

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  1. P. Iwangoff
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  2. A. Enz
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Iwangoff, P., Enz, A. Inhibition of phosphodiesteras by dihydroergotamine and hydergine in various organs of the cat in vitro. Experientia 29, 1067–1069 (1973). https://doi.org/10.1007/BF01946723

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  • DOI: https://doi.org/10.1007/BF01946723

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