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Immunomodulating peptides

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References

  1. Abiko, T., Kumikawa, M., and Sekino, H., Inhibition effect of rosette formation between human lymphocytes and sheep erythrocytes by specific heptapeptide isolated from uremic fluid and its analogs. Biochem. biophys. Res. Commun.86 (1979) 945–952.

    CAS  PubMed  Google Scholar 

  2. Adam, A., and Lederer, E., Muramyl peptides: immunomodulators, sleep factors, and vitamins. Med. Res. Rev.4 (1984) 111–152.

    CAS  PubMed  Google Scholar 

  3. Auriault, C., Joseph, M., Tartar, A., Bout, D., Tonnel, A. B., and Capron, A., Regulatory role of a tripeptide (TKP) from the second constant domain of immunoglobulin G. I. Inhibition of rat and human macrophage activities. Int. J. Immunopharmac.7 (1985) 73–79.

    CAS  Google Scholar 

  4. Bach, J.-F., Thymulin (FTS-Zn). Clinics Immun. Allergy3 (1983) 133–156.

    CAS  Google Scholar 

  5. Bach, J.-F., Synthetic thymic hormones; in: Thymic Factor Therapy, vol. 16, pp. 21–29. Eds N. A. Byrom and J. R. Hobbes. Raven Press, New York 1984.

    Google Scholar 

  6. Bach, J.-F., and Kaiserlian, D., Significance and value of thymic preparations used for Immunotherapy, Cancer Treatment Symposia, vol. 1, pp. 95–99, U.S. Dept. of Health, NIH 1985.

  7. Bessler, W. G., Cox, M., Wiesmüller, K. H., and Jung, G., The mitogenic principle ofEscherichia coli lipoprotein: B-lymphocyte mitogenicity of the synthetic analogue palmitoyl-tetrapeptide (Pam-Ser-Ser-Asn-Ala). Biochem. biophys. Res. Commun.121 (1984) 55–61.

    CAS  PubMed  Google Scholar 

  8. Bessler, W. G., Johnson, R. B., Wiesmüller, K., and Jung, G., B-lymphocyte mitogenicity in vitro of a synthetic lipopeptide fragment derived from bacterial lipoprotein. Hoppe-Seyler's. Z. physiol. Chem.363 (1982) 767–770.

    CAS  Google Scholar 

  9. Blalock, J. E., and Smith, E. M., A complete regulatory loop between the immune and neuroendocrine systems. Fedn Proc.44 (1985) 108–111.

    CAS  Google Scholar 

  10. Borel, J. F., Ciclosporine, in: Textbook of Immunopharmacology, pp. 315–324. Eds M. M. Dale and J. C. Foreman, Blackwell Scientific Publications, Oxford 1984.

    Google Scholar 

  11. Braun, V., Covalent lipoprotein from the outer membrane ofEscherichia coli. Biochim. biophys. Acta415 (1975) 335–377.

    CAS  PubMed  Google Scholar 

  12. Chedid, L., Bahr, G. M., Farrokh, Z., Modabber, F. Z., Dinarello, C. A., and Wolff, S. M., Mise en évidence d'une structure bactérienne dans deux médiateurs humains: un facteur favorisant le sommeil et une monokine. C. r. Acad. Sci., Paris297 (1983) 209–212.

    CAS  Google Scholar 

  13. Chedid, L., Bahr, G. M., Riveau, G., and Krueger, J. M., Specific absorption with monoclonal antibodies to muramyl dipeptide of the pyrogenic and somnogenic activities of rabbit monokine. Proc. natn. Acad. Sci. USA81 (1984) 5888–5891.

    CAS  Google Scholar 

  14. Chedid, L. A., Parant, M. A., Audibert, F. M., Riveau, G. J., Parant, F. J., Lederer, E., Choay, J. P., and Lefrancier, P. L., Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity. Infect. Immun.35 (1982) 417–424.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Edgington, T. S., Curtiss, L. K., and Plow, E. F., A linkage between the hemostatic and immune systems embodied in the fibrinolytic release of lymphocyte suppressive peptides. J. Immun.134 (1985) 471–477.

    CAS  PubMed  Google Scholar 

  16. Ellouz, F., Adam, A., Ciorbaru, R., and Lederer, A., Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochem. biophys. Res. Commun.59 (1974) 1317–1325.

    CAS  PubMed  Google Scholar 

  17. Gerdin, B., Saldeen, T., Roszkowski, W., Szimigielski, S., Stachurska, J., and Kopec, M., Immunosuppressive effect of vasoactive peptides derived from human fibrinogen. Thrombosis Res.18 (1980) 461–468.

    CAS  Google Scholar 

  18. Girmann, G., Pees, H., Schwarze, G., and Scheurlen, P. G., Immunosuppression by molecular fibrinogen degradation products in cancer. Nature259 (1976) 399–401.

    CAS  PubMed  Google Scholar 

  19. Goldstein, A. L., Slatter, F. D., and White, A., Preparation, assay and partial purification of a thymic lymphocytopoietic factor (thymosin). Proc. natn. Acad. Sci. USA56 (1966) 1010–1014.

    CAS  Google Scholar 

  20. Hazum, E., Chang, J. K., and Cuatrecasas, P., Specific nonopiate receptors forβ-endorphins. Science205 (1979) 1033–1035.

    CAS  PubMed  Google Scholar 

  21. Hemmi, K., Takeno, H., Okada, S., Nakaguchi, O., Kitaura, Y., and Hashimoto, M., Total synthesis of FK-156 isolated from a Streptomyces as an immunostimulating peptide: application of a novel copper chelate amino protection. J. Am. chem. Soc.103 (1981) 7026–7030.

    CAS  Google Scholar 

  22. Izumi, S., Nakahara, K., Gotoh, T., Hashimoto, S., Kino, T., Okubara, M., Aoki, G., and Imanaka, H., Antitumor effects of novel immunoactive peptides, FK-156 and its synthetic derivatives. J. Antibiot.36 (1983) 566–574.

    CAS  Google Scholar 

  23. Janusz, M., Lisowski, J., and Franek, F., Isolation and characterization of a proline-rich polypeptide from ovine colostrum. FEBS Lett.49 (1974) 276–279.

    CAS  PubMed  Google Scholar 

  24. Johnson, H. M., Smith, E. M., Torres, B. A., and Blalock, J. E., Regulation of the in vitro antibody response by neuroendocrine hormones. Proc. natn. Acad. Sci. USA79 (1982) 4171–4174.

    CAS  Google Scholar 

  25. Jollès, P., A possible physiological function of lysozyme. Biomedicine25 (1976) 275–276.

    PubMed  Google Scholar 

  26. Jollès, P., Parker, F., Floc'h, F., Migliore, D., Alliel, P., Zerial, A., and Werner, G. H., Immunostimulating substances from human casein. J. Immunopharmac.3 (1982/82) 363–369.

    Google Scholar 

  27. Koff, W. C., Showalter, S. D., Hampar, B., and Fidler, I. J., Protection of mice against fatal herpes simplex type 2 infection by liposomes containing muramyl tripeptide. Science228 (1985) 495–497.

    CAS  PubMed  Google Scholar 

  28. Kopec, M., Roszowski, W., Gerdin, B., and Saldeen, T., Effects of peptides derived from fibrinogen proteolysis on immune reactions and tumor growth, in: Fibrinogen: Recent Biochemical and Medical Aspects, pp. 355–360, Walter de Gruyter and Co, Berlin, New York, 1982.

    Google Scholar 

  29. Krönke, M., Leonard, W. J., Depper, J. M., Arya, S. K., Wong-Staal, F., Gallo, R. C., Waldmann, T. A., and Greene, W. C., Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc. natn. Acad. Sci. USA81 (1984) 5214–5218.

    Google Scholar 

  30. Krueger, J., Walter, J., and Levin, C., Factor S and related somnogens: an immune theory for slow-wave sleep, in: Brain Mechanisms of Sleep, pp. 253–275. Eds D. J. McGinty et al. Raven Press, New York 1985.

    Google Scholar 

  31. Low, T. L. K., and Goldstein, A. L., Thymosins: structure, function and therapeutic applications. Thymus6 (1984) 27–42.

    CAS  PubMed  Google Scholar 

  32. Masek, K., Seifert, J., Flegel, M., Krojidlo, M., and Kolinsky, J., The immunomodulatory property of a novel synthetic compound, adamantylamide dipeptide. Meth. Find. exp. clin. Pharmac.6 (1984) 667–669.

    CAS  Google Scholar 

  33. McCain, H. W., Lamster, I. B., Bozzone, J., and Grbic, J. T.,β-endorphin modulates human immune activity via nonopiate receptor mechanisms. Life Sci.3 (1982) 1619–1624.

    Google Scholar 

  34. Migliore-Samour, D., Bouchaudon, J., Floc'h, F., Zerial, A., Ninet, L., Werner, G. H., and Jollès, P., A short lipopeptide representative of a new family of immunological adjuvants devoid of sugar. Life Sci.26 (1980) 883–888.

    CAS  PubMed  Google Scholar 

  35. Migliore-Samour, D., Bouchaudon, J., Floc'h, F., Zerial, A., Ninet, L., Werner, G. H., and Jollès, P., Propriétés immunostimulantes et adjuvantes d'un lipopeptide de faible poids moléculaire. C.r. Acad. Sci., Paris, Série D289 (1979) 473–476.

    CAS  Google Scholar 

  36. Migliore, D., and Jollès, P., Contribution to the study of the structure of adjuvant waxes D from Mycobacteria: isolation of a peptidoglycan. FEBS Lett.7 (1968) 7–9.

    Google Scholar 

  37. Miller, J. F. A. P., Immunological function of the thymus. Lancet2 (1961) 748–749.

    CAS  PubMed  Google Scholar 

  38. Mine, Y., Yokota, Y., Wakai, Y., Fukuda, S., Nishida, M., Goto, S., and Kuwahara, S., Immunoactive peptides FK-156 and FK-565. I. Enhancement of host resistance to microbial infection in mice. J. Antibiot.36 (1983) 1045–1050.

    CAS  Google Scholar 

  39. Mitsuma, T., Nogimori, T., and Chaya, M., Tuftsin stimulates thyrotropin secretion in rats. Experientia41 (1985) 113–114.

    CAS  PubMed  Google Scholar 

  40. Najjar, V., and Fridkin, M., Antineoplastic, immunogenic and other effects of the tetrapeptide tuftsin: a natural macrophage activator. Ann. N.Y. Acad. Sci.419 (1983) 1–273.

    CAS  PubMed  Google Scholar 

  41. Niaudet, P., Beaurain, G., Leibowitch, J., and Bach, J.-F., In vitro characteristics on human lymphocyte functions of a new immunomodulatory agent, a cyclic peptide, cyclomunine. Clin. exp. Immun.42 (1980) 315–323.

    CAS  PubMed  PubMed Central  Google Scholar 

  42. O'Dorisio, M. S., Hermina, N. S., O'Dorisio, T. M., and Balcerzak, S. P., Vasoactive intestinal polypeptide modulation of lymphocyte adenylate cyclase. J. Immun.127 (1981) 2551–2554.

    CAS  PubMed  Google Scholar 

  43. Ottaway, C. A., and Greenberg, G. R., Interaction of vasoactive intestinal peptide with mouse lymphocytes: specific binding and the modulation of mitogen responses. J. Immun.132 (1984) 417–423.

    CAS  PubMed  Google Scholar 

  44. Parant, M. A., Audibert, F. M., Chedid, L. A., Level, M. R., Lefrancier, P. L., Choay, J. P., and Lederer, E., Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs. Infect. Immun.27 (1980) 826–831.

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Parker, F., Migliore-Samour, D., Floc'h, F., Zerial, A., Werner, G. H., Jollès, J., Casaretto, M., Zahn, H., and Jollès, P., Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties. Eur. J. Biochem.145 (1984) 677–682.

    CAS  PubMed  Google Scholar 

  46. Parker, F., Migliore-Samour, D., Floc'h, F., Zerial, A., Werner, G. H., and Jollès, P., (1985) unpublished data.

  47. Payan, D. G., Brewster, D. R., and Goetzl, E. J., Specific stimulation of human T lymphocytes by substance P1. J. Immun.131 (1983) 1613–1615.

    CAS  PubMed  Google Scholar 

  48. Payan, D. G., Brewster, D. R., and Goetzl, E. J., Stereospecific receptors for substance P on cultured human IM-9 lymphoblasts. J. Immun.133 (1984) 3260–3265.

    CAS  PubMed  Google Scholar 

  49. Payan, D. G., Brewster, D. R., Missirian-Bastian, A., and Goetzl, E. J., Substance P recognition by a subset of human T lymphocytes. J. clin. Invest.74 (1984) 1532–1539.

    CAS  PubMed  PubMed Central  Google Scholar 

  50. Payan, D. G., Hess, C. A., and Goetzl, E. J., Inhibition by somatostatin of the proliferation of T lymphocytes and Molt-4 lymphoblasts. Cell Immun.84 (1984) 433–438.

    CAS  Google Scholar 

  51. Plotnikoff, N. P., Murgo, A. J., Miller, G. C., Corder, C. N., and Faith, R. E., Enkephalins: immunomodulators. Fedn Proc.44 (1985) 118–122.

    CAS  Google Scholar 

  52. Plow, E. F., Freaney, D., and Edgington, T. S., Inhibition of lymphocyte protein synthesis by fibrinogen-derived peptides. J. Immun.128 (1982) 1595–1599.

    CAS  PubMed  Google Scholar 

  53. Renoux, G., The thymic factor system. Biomed. Pharmacother.37 (1983) 433–440.

    CAS  PubMed  Google Scholar 

  54. Rola-Pleszczynski, M., Bolduc, D., Forand, S., and St. Pierre, S., Induction of cytotoxic cell activity by peptide fragments ofβ 2-microglobulin. Immunopharmacology9 (1985) 39–43.

    CAS  PubMed  Google Scholar 

  55. Shimoda, K., and Yazaki, Y., Binding sites for angiotensin II in human mononuclear leucocytes. J. Biochem.84 (1978) 1013–1019.

    Google Scholar 

  56. Staroscik, K., Janusz, M., Zimecki, M., Wieczorek, Z., and Lisowski, J., Immunological active nonapeptide fragment of a proline-rich polypeptide from ovine colostrum: amino acid sequence and immunoregulatory properties. Molec. Immun.20 (1983) 1277–1282.

    CAS  PubMed  Google Scholar 

  57. Takeno, H., Okada, S., Hemmi, K., Aratani, M., Kitaura, Y., and Hashimoto, M., Studies on structure-activity relationship of FK-156, an immunostimulating peptide, and related compounds. I. Synthesis of stereoisomeric analogues of FK-156. Chem. pharm. Bull.32 (1984) 2925–2931.

    CAS  Google Scholar 

  58. Thomas, D. W., and Hoffman, M. D., Identification of macrophage receptors for angiotensins: a potential role in antigen uptake for T lymphocyte responses J. Immun.132 (1984) 2807–2812.

    CAS  PubMed  Google Scholar 

  59. Umezawa, H., Small molecular immunomodifiers of microbial origin, in: Fundamental and Clinical Study of Bestatin, pp. 1–245. Eds The Japan Scientific Society Press, Tokyo and Pergamon Press, Oxford, New York 1981.

    Google Scholar 

  60. Umezawa, H., and Ishizuka, M., Low molecular weight immunomodiffers produced by microorganisms. Int. J. clin. pharmac. Ther. Toxic.23 (1985) S9-S13.

    Google Scholar 

  61. Werner, G. H., Floc'h, F., Bouchaudon, J., Zerial, A., Migliore-Samour, D., and Jollès, P., Low molecular weight synthetic lipopeptides: a new class of immunopotentiating substances. Current Concepts in Human Immunology and Cancer Immunomodulation (1982) 645–652, Elsevier Biomedical Press.

  62. Wieczorek, Z., Zimecki, M., Janusz, M., Staroscik, K., and Lisowski, J., Proline-rich polypeptide from ovine colostrum: its effect on skin permeability and on the immune response. Immunology36 (1979) 875–881.

    CAS  PubMed  PubMed Central  Google Scholar 

  63. Wybran, J., Enkephalins and endorphins as modifiers of the immune system: present and future. Fedn Proc.44 (1985) 92–94.

    CAS  Google Scholar 

  64. Wybran, J., Appelboom, T., Famaey, J. P., and Govaerts, A., Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood lymphocytes. J. Immun.123 (1979) 1068–1070.

    CAS  PubMed  Google Scholar 

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Werner, G.H., Floc'h, F., Migliore-Samour, D. et al. Immunomodulating peptides. Experientia 42, 521–531 (1986). https://doi.org/10.1007/BF01946691

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