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Phosphate transport inTrypanosoma cruzi

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Zusammenfassung

Epimastigoten vonTrypanosoma cruzi sind für Orthophosphate (P i ) relativ undurchlässig. Man kann trotzdem bei zellen, die aus Ortophosphat armen Kulturen stammen, einen signifikanten Übertritt von Ortophosphat ins Zellinnere messen. Bei diesen Zellen ist die Geschwindigkeit des P i -Transportes ins Zellinnere trotz eines diesem Vorgang entgegenwirkenden Phosphat-Konzentrationsgradienten etwa 5 mal grösser als die der P i -Abgabe aus dem Zellinnern des umgebenden Mediums. Die Durchlässigkeitsschranke für P i wird durch 3 mM Jodacetat zerstört.

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Literatur

  1. The abbreviations used were: P i , inorganic orthophosphate; P7, heat and acid-labile phosphate, TCA-soluble phosphate; P as , total TCA-soluble phosphate; P o , P as less P i +P7; P i , lipid phosphate; P r , TCA-insoluble phosphate less P i ; P s , total phosphate; TCA, trichloracetic acid.

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Authors and Affiliations

  1. Cátedra de Química Biológica, Facultad de Medicina, Paraguay 2155, Buenos Aires, (Argentina)

    J. F. de Boiso (Career Investigator, Conicet) & A. O. M. Stoppani

Authors
  1. J. F. de Boiso
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  2. A. O. M. Stoppani
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Additional information

This work was supported by grants of Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina), the Instituto Nacional de Farmacología, and the Wellcome Trust.

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de Boiso, J.F., Stoppani, A.O.M. Phosphate transport inTrypanosoma cruzi . Experientia 28, 1162–1164 (1972). https://doi.org/10.1007/BF01946144

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