Summary
The solubility of granulopoiesis inhibiting factor (GIF) in various aqueous and organic solvents was investigated. GIF is soluble in water, 10% acetic acid, and 10% pyridine. It is not extractable by 1-butanol at low and high pH. A high solubility was found in polar organic solvents (ethanol-acetone 9∶1, and chloroformmethanol 1∶1), whereas GIF seems to be insoluble in pure chloroform.
Similar content being viewed by others
References
T. Rytömaa andK. Kiviniemi, Cell Tissue Kinet.1, 329 (1968).
W. R. Paukovits, Natn. Cancer Inst. Monogr.38, 147 (1973).
O. D. Laerum andH. R. Maurer, Virchow's Arch (B) Zellpath.14, 293 (1973).
B. I. Lord, Br. J. Cancer29, 407 (1974).
J. A. Vilpo, Eur. J. Cancer9, 515 (1973).
W. R. Paukovits, Cell Tissue Kinet.4, 539 (1971).
W. R. Paukovits, Hoppe Seyler's Z. physiol. Chem.354, 1228 (1973).
W. R. Paukovits, 8th Paterson Symp. on control of haemopoiesis (Manchester 1973), Br. J. Cancer29, 84 (1974).
S. C. S. Chang, D. Sikkema andE. Goldwasser, Biochem. biophys. Res. Commun.57, 399 (1974).
R. Süss andM. Volm, Naturwissenschaften55, 134 (1968).
W. R. Paukovits, Expl. Path.10, 348 (1975).
P. H. Bell, Biochemistry9, 1665 (1970).
G. Krell andH. Bachmayer, Eur. J. Biochem.20, 344 (1971).
W. Jones, Union Int. Res. Centre, pers. commun. (1974).
J. P. Lewis, Proc. Soc. exp. Biol. Med.142, 293 (1973).
A. E. Bateman, Cell Tissue Kinet.7, 451 (1974).
A. S. Pacsa, J. natn. Cancer Inst., USA,53, 1399 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Paukovits, W.R., Paukovits, J.B. The solubility properties of granulopoiesis inhibiting factor. Experientia 31, 1357–1359 (1975). https://doi.org/10.1007/BF01945825
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01945825