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Excess dietary lysine induces hypercholesterolemia in chickens

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Summary

Lysine and arginine supplements were fed to 5-day-old chicks to test whether they would develop hypercholesterolemia in response to excess lysine in a fashion similar to mammals. Chicks developed hypercholesterolemia with a 4–5% lysine but not with arginine supplementation. These results indicate the lysine induced hypercholesterolemia is not due to anaplerotic interactions of arginine and lysine with the urea cycle.

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Authors and Affiliations

  1. Harlan E. Moore Heart Research Foundation, 503 S. Sixth St., 61820, Champaign, (IL), USA

    D. E. Leszczynski & F. A. Kummerow

  2. Burnsides Research Laboratory, Department of Food Science, University of Illinois, 1208 W. Pennsylvania Avenue, 61801, Urbana, (IL), USA

    D. E. Leszczynski & F. A. Kummerow

Authors
  1. D. E. Leszczynski
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  2. F. A. Kummerow
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Additional information

Acknowledgment. This work was funded in part through a fellowship (D.L.) from the American Heart Association, Illinois affiliate and a grant from the National Livestock and Meat Board.

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Leszczynski, D.E., Kummerow, F.A. Excess dietary lysine induces hypercholesterolemia in chickens. Experientia 38, 266–267 (1982). https://doi.org/10.1007/BF01945105

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