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The role of calcium in aggregation and development ofDictyostelium

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Abstract

Changes in cytosolic Ca2+ play an important role in a wide array of cell types and the control of its concentration depends upon the interplay of many cellular constituents. Resting cells maintain cytosolic calcium ([Ca2+]i) at a low level in the face of steep gradients of extracellular and sequestered Ca2+. Many different signals can provoke the opening of calcium channels in the plasma membrane or in intracellular compartments and cause rapid influx of Ca2+ into the cytosol and elevation of [Ca2+]i. After such stimulation Ca2+ ATPases located in the plasma membrane and in the membranes of intracellular stores rapidly return [Ca2+]i to its basal level. Such responses to elevation of [Ca2+]i are a part of an important signal transduction mechanism that uses calcium (often via the binding protein calmodulin) to mediate a variety of cellular actions responsive to outside influences.

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Authors and Affiliations

  1. Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK

    P. C. Newell & J. D. Gross

  2. Fakultät für Biologie, Universität Konstanz, Postfach 5560, D-78434, Konstanz, Germany

    D. Malchow

Authors
  1. P. C. Newell
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  2. D. Malchow
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  3. J. D. Gross
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Newell, P.C., Malchow, D. & Gross, J.D. The role of calcium in aggregation and development ofDictyostelium. Experientia 51, 1155–1165 (1995). https://doi.org/10.1007/BF01944733

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  • DOI: https://doi.org/10.1007/BF01944733

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