Summary
We have measured the electro-olfactogram produced by four odorants, nicotine, i-pentyl acetate, i-pentanoic acid and cineole from twelve positions on an in vitro preparation of rat olfactory tissue. Each odorant shows a different pattern of response over the twelve positions which can be explained by differences in olfactory receptor populations between regions of the rat olfactory epithelium.
The result for nicotine is further evidence that there are olfactory receptors which are stimulated by nicotine when it is presented as a vapour.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Getchell, T. V., Physiol. Rev.66 (1986) 772.
Lancet, D., A. Rev. Neurosci.9 (1986) 329.
Mozell, M. M., and Jagodowicz, M., Science (Washington)181 (1973) 1247.
Getchell, T. V., Margolis, F. L., and Getchell, M. L., Prog. Neurobiol.23 (1984) 317.
Shirley, S. G., Polak, E. H., Edwards, D. A., Wood, M. A., and Dodd, G. H., Biochem. J.245 (1987) 185.
Shirley, S. G., Polak, E. H., Mather, R. A., and Dodd, G. H., Biochem. J.245 (1987) 175.
Revial, M. F., Sicard, G., Duchamp, A., and Holley, A., Chem. Senses7 (1982) 175.
Shirley, S. G., Robinson, C. J., Dickinson, K., Aujla, R., and Dodd, G. H., Biochem. J.240 (1986) 605.
Sklar, P. B., Anholt, R. R. H., and Snyder, S. H., J. biol. Chem.261 (1986) 15538.
Mustaparta, H., Acta. physiol. scand.82 (1971) 154.
Daval, G., Leveteau, J., and MacLeod, P., J. Physiol. Paris76 (1980) 559.
Mackay-Sim, A., and Kubie, J. L., Chem. Senses6 (1981) 249.
Menco, B. Ph. M., in: Nasal Tumors in Animals and Man, vol. 1, p. 45. Eds G. Reznik and S. F. Stinson. CRC Press, Florida 1983.
Pederson, P. E., Jastreboff, P. J., Stewart, W. B., and Shepherd, G. M., J. comp. Neurobiol.250 (1986) 93.
Astic, L., and Saucier, D., Brain Res. Bull.16 (1986) 445.
Saucier, D., and Astic, L., Brain Res. Bull.16 (1986) 455.
Thommesen, G., and Doving, K. B., Acta. physiol. scand.99 (1977) 270.
Edwards, D. A., Mather, R. A., Shirley, S. G., and Dodd, G. H., Experientia43 (1987) 868.
Menco, B. Ph. M., Cell Tissue Res.207 (1980) 183.
Shirley, S. G., Chem. Senses (1987) in press.
Pevsner, J., Sklar, P. B., and Snyder, S. H., Proc. natl Acad. Sci. USA83 (1986) 4942.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Edwards, D.A., Mather, R.A. & Dodd, G.H. Spatial variation in response to odorants on the rat olfactory epithelium. Experientia 44, 208–211 (1988). https://doi.org/10.1007/BF01941707
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01941707