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DNA synthesis in exocrine and endocrine pancreas after partial hepatectomy in Syrian golden hamsters

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3H-thymidine autoradiography showed an enhanced DNA synthesis, in acinar and islet cells of pancreas after partial hepatectomy in syrian golden hamsters. A significant nuclear labeling index of acinar cells was observed between 48 and 84 h and reached control levels by 120 h. An increased labeling index of islet cells was also observed, however, this increase was not statistically significant. These results indicate growth factor(s) produced after partial hepatectomy is capable of inducing DNA synthesis in pancreas.

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Authors and Affiliations

  1. Department of Pathology, Northwestern University Medical School, 303 East Chicago Avenue, 60611, Chicago, Illinois, USA

    M. S. Rao & V. Subbarao

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  1. M. S. Rao
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  2. V. Subbarao
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This work is supported by NIH grant CA 36043.

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Rao, M.S., Subbarao, V. DNA synthesis in exocrine and endocrine pancreas after partial hepatectomy in Syrian golden hamsters. Experientia 42, 833–834 (1986). https://doi.org/10.1007/BF01941543

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  • DOI: https://doi.org/10.1007/BF01941543

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