Skip to main content
Log in

Receptor ontogeny and hormonal imprinting

  • Multi-Author Review
  • Development of Hormone Receptors
  • Published:
Experientia Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Alexander, R. W., Galper, J. B., Neer, E. J., and Smith, T. W., Nonco-ordinate development of β-adrenergic receptors and adenylate cyclase in chick heart. Biochem. J.204 (1982) 825–830.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Amir, S. M., Sullivan, R. C., and Ingbar, S. H., Binding of bovine thyrotropin to receptor in rat testis and its interaction with gonadotropins. Endocrinology103 (1978) 101–111.

    Article  CAS  PubMed  Google Scholar 

  3. Azukizawa, M., Kutzman, G., Pekary, A. E., and Hershman, J. K., Comparison of the binding characterisitics of bovine thyrotropin and human chorionic gonadotropin to thyroid plasma membrane. Endocrinology101 (1977) 1880–1889.

    Article  CAS  PubMed  Google Scholar 

  4. Balázsi, I., Stützel, M., Varsányi-Nagy, M., and Karádi, I., Fat cell insulin receptors in children and adults. Diabetologia15 (1978) 217.

    Google Scholar 

  5. Barraclough, C. A., Production of anoovulatory, sterile rats by single injection of testosterone propionate. Endocrinology68 (1961) 61–67.

    Article  Google Scholar 

  6. Barrington, E. J. W., Evolutionary aspects of hormonal structure and function, in: Comparative endocrinology. Eds. P. J. Gaillard and H. Boer. Elsevier-North Holland, Amsterdam 1978.

    Google Scholar 

  7. Barrington, E. J. W., Hormones and evolution. Academic Press, London/New York 1979.

    Google Scholar 

  8. Bern, H. A., Gorski, P. A., and Kawashima, S., Long term effects of perinatal hormone administration. Science181 (1973) 189–190.

    Article  CAS  PubMed  Google Scholar 

  9. Blazquez, E. B., Rubalcava, B., Montesano, R., Orci, L, and Unger, R. H., Development of insulin and glucagon binding and the adenylate cyclase response in liver membranes of the prenatal, postnatal and adult rat: evidence of glucagon ‘resistance’. Endocrinology98 (1976) 1014–1023.

    Article  CAS  PubMed  Google Scholar 

  10. Campbell, P. S., An early effect of testosterone propionate upon hypothalamic function in the neonatal rat. Experientia39 (1983) 108–109.

    Article  CAS  PubMed  Google Scholar 

  11. Csaba, G., Phylogeny and ontogeny of hormone receptors: the selection theory of receptor formation and hormonal imprinting. Biol. Rev.55 (1980) 47–63.

    Article  CAS  PubMed  Google Scholar 

  12. Csaba, G., Ontogeny and phylogen of hormone receptors. Karger, Basel/New York 1981.

    Google Scholar 

  13. Csaba, G., The present state in the phylogeny and ontogeny of hormone receptors. Horm. Metab. Res.16 (1984) 329–335.

    Article  CAS  PubMed  Google Scholar 

  14. Csaba, G., Hormone overlap hormonal imprinting and receptor memory in tissue culture, in: Tissue culture and Research. Eds. P. Röhlich and E. Bácsy. Hung. Acad. Sci. Budapest 1984.

    Google Scholar 

  15. Csaba, G., The unicellularTetrahymena as model cell for receptor research. Int. Rev. Cytol.95 (1985) 327–377.

    Article  CAS  PubMed  Google Scholar 

  16. Csaba, G., Why do hormone receptors arise? Experientia42 (1986) 715–718.

    Article  CAS  PubMed  Google Scholar 

  17. Csaba, G., and Bohdaneczky, E., Receptor development and hormone action. Effects of insulin and epinephrine on the glucagon content of newborn rat liver cultures. Acta physiol. hung58 (1981) 15–20.

    CAS  PubMed  Google Scholar 

  18. Csaba, G., and Bohdaneczky, E., Induction of imprinting and ‘memory’ in Chang liver cells with lectin. Cell. molec. Biol.30 (1984) 1–4.

    CAS  Google Scholar 

  19. Csaba, G., and Dobozy, O., The sensitivity of sugar receptor —analysis in adult animals of influences exerted at neonatal age. Endokrinologie69 (1977) 227–232.

    CAS  PubMed  Google Scholar 

  20. Csaba, G., Dobozy, O., and Kaizer, G., Study of FSH-TSH functional overlap by cockerel testicle. Horm. Metab. Res.11 (1979) 689–692.

    Article  CAS  PubMed  Google Scholar 

  21. Csaba, G., Dobozy, O., and Kaizer, G., FSH-TSH functional overlap in cockerel testicle. Durable amplification of the hormone receptors by treatment at hatching. Horm. Metab. Res.13 (1981) 177–179.

    Article  CAS  PubMed  Google Scholar 

  22. Csaba, G., Dobozy, O., and Deák, B. M., HCG-TSH overlap and induction of Galli-Mainini reaction with TSH in adult male frogs. Horm. Metab. Res.14 (1982) 617–618.

    Article  CAS  PubMed  Google Scholar 

  23. Csaba, G., Dobozy, O., and Deák, B. M., Interaction of thyrotropin (TSH) and gonadotropins in the function of genital organs I. Acta physiol. hung.61 (1983) 137–140.

    CAS  PubMed  Google Scholar 

  24. Csaba, G., Dobozy, O., Shahin, M. A., and Dalló, J., Impact of a single neonatal gonadotropin (FSH+LH) or thyrotropin (TSH) treatment on the sexual behaviour of the adult male rat. Med. Biol.62 (1984) 64–66.

    CAS  PubMed  Google Scholar 

  25. Csaba, G., and Inczefi-Gonda, Á., Effect of benzo-a-pyrene treatment of neonatal and growing rats on steroid receptor binding capacity in adulthood. Gen. Pharmac.15 (1984) 557–558.

    Article  CAS  Google Scholar 

  26. Csaba, G., Inczefi-Gonda, Á., Dobozy, O., Varró, A., and Rablóczky, G., Impact of neonatal treatment with caridoactive glycosides (digoxin, ouabain) on receptor binding capacity, blood level and cardiac function in the adult rat. Extension of the imprinting theory. Gen. Pharmac.14 (1983) 709–711.

    Article  CAS  Google Scholar 

  27. Csaba, G., Inczefi-Gonda, Á., and Dobozy, O., Hereditary transmission on the F1 generation of hormonal imprinting (receptor memory) induced in rats by neonatal exposure to insulin. Acta physiol. hung.63 (1984) 93–99.

    CAS  PubMed  Google Scholar 

  28. Csaba, G., Inczefi-Gonda, Á., and Dobozy, O., Imprinting by steroids: a single neonatal treatment with diethylstilbestrol (DES) or allylestrenol (AE) gives rise to a lasting decrease in the number of rat uterine receptors. Acta physiol. hung., in press (1985).

  29. Csaba, G., and Nagy, S. U., Plasticity of hormone receptors and possibility of their deformation in neonatal age. Experientia32 (1976) 656–657.

    Article  Google Scholar 

  30. Csaba, G., and Nagy, S. U., Influence of the neonatal suppression of TSH production (neonatal hyperthyroidism) on response to TSH in adulthood. J. Endocr. Invest.8 (1985) 557–561.

    Article  CAS  PubMed  Google Scholar 

  31. Csaba, G., and Nagy, S. U., Influence of a single neonatal melatonin treatment on the basal and thyrotropin or melatonin modified blood thyroxine level of rats in adulthood. Acta physiol. hung. in press (1986).

  32. Csaba, G., Németh, G., and Vargha, P., Development and persistence of receptor ‘memory’ in a unicellular model system. Expl Cell Biol.52 (1982) 291–294.

    Google Scholar 

  33. Csaba, G., Rónai, A., László, V., Darvas, Zs., and Berzétei, I., Amplification of hormone receptors by neonatal oxytocin and vasopressin treatment. Horm. Metab. Res.12 (1980) 28–31.

    Article  CAS  PubMed  Google Scholar 

  34. Csaba, G., Rónai, A., Dobozy, O., and Berzétei, I., Impact of neonatal catecholamine treatment on adult response to vasopressin and norepinephrine. Expl clin. Endocr.84 (1984) 153–158.

    Article  CAS  Google Scholar 

  35. Csaba, G., Shahin, M. A., and Dobozy, O., The overlapping effects of gonadotropins and TSH on embryonic chicken gonads. Archs Anat. Hist. Embryol.63 (1980) 31–38.

    CAS  Google Scholar 

  36. Csaba, G., Sudár, F., and Dobozy, O., Triiodothyronine receptors in lymphocytes of newborn and adult rats. Horm. Metab. Res.9 (1977) 499–501.

    Article  CAS  PubMed  Google Scholar 

  37. Csaba, G., and Sudár, F., Differentiation dependent alterations in lymphoytic triiodothyronine reception. Horm. Metab. Res.10 (1978) 425–426.

    Article  Google Scholar 

  38. Csaba, G., Szeberényi, Sz., and Dobozy, O., Influence of single neonatal treatment with allylestrenol or diethylstilbestrol (DES) on microsomal enzyme activity in adulthood. Med. Biol, in press (1986).

  39. Csaba, G., and Török, O., Impact of FSH-TSH overlap on the growth of Chinese hamster ovary (CHO) cell culture. Acta biol. hung.34 (1983) 433–434.

    CAS  PubMed  Google Scholar 

  40. Csaba, G., Török, O., and Kovács, P., Hormonal imprinting in cell culture I. Impact of single exposure to insulin on cellular insulin binding capacity in permanent cell lines. Acta physiol. hung.64 (1984) 57–63.

    CAS  PubMed  Google Scholar 

  41. Csaba, G., Török, O., and Kovács, P., Hormonal imprinting in cell culture II. Induction of hormonal imprinting and thyrotropin (TSH) — gonadotropin (FSH) overlap in a Chinese hamster ovary (CHO) cell line. Acta physiol. hung.64 (1984) 135–138.

    CAS  PubMed  Google Scholar 

  42. Csaba, G., and Ubornyák, L., Incorporation of hormones and hormone like materials by rat lymphocytes of different ontogenetic stages. Expl. clin. Endocr.22 (1983) 68–72.

    Google Scholar 

  43. Dobozy, O., Balkányi, L., and Csaba, G., Thyroid cell hyporesponsiveness in cockerels treated with follicle stimulating hormone (FSH) or thyrotropin (TSH) at hatching. Horm. Metab. Res.13 (1981) 587–588.

    Article  CAS  PubMed  Google Scholar 

  44. Döhler, K-D., Is female sexual differentiation hormonemediated? TINS1 (1978) 138–140.

    Google Scholar 

  45. Döhler, K-D., Srivastava, S. S., and Gorski, R., Postnatal tamoxifen treatment interferes with differentiation of the sexually dimorphic nucleus of the preoptic area in both male and female rats. Endocrinology108 suppl. (1981) 187.

    Google Scholar 

  46. Döhler, K-D., Nordeen, E. J., and Yahr, P., Perinatal treatment of rats with an estrogen antagonist impairs estradiol uptake into brain cell nuclei in adulthood. Neurosci. Lett. suppl.10 (1982) 149–150.

    Google Scholar 

  47. Dörner, G., Environment-dependent brain differentiation and fundamental processes of life. Acta biol. med. germ.33 (1974) 129–148.

    PubMed  Google Scholar 

  48. Dubois, J. D., and Dussault, J. H., Ontogenesis of thyroid function in the neonatal rat. Thyroxine (T4) and triiodothyronine (T3) production rates. Endocrinology101 (1977) 438–439.

    Article  Google Scholar 

  49. Dussault, J. H., Coulombre, P., and Walker, P., Effects of neonatal hyperthyroidism on the development of the hypothalamic-pituitarythyroid axis in the rat. Endocrinology110 (1982) 1037–1042.

    Article  CAS  PubMed  Google Scholar 

  50. Dussault, J. H., and Labrie, F., Development of the hypothalamicpituitary-thyroid axis in the neonatal rat. Endocrinology97 (1975) 1321–1324.

    Article  CAS  PubMed  Google Scholar 

  51. Fischer, D. A., and Klein, A. H., Thyroid development and disorders of thyroid function in the newborn. New Engl. J. Med.304 (1981) 702–712.

    Article  Google Scholar 

  52. Fontaine, Y-A., and burzawa-Gerard, E., Esquisse de l'evolution des hormones gonadotropes et thyrotropes des vertebrés. Gen. comp. Endocr.32 (1977) 341–347.

    Article  CAS  PubMed  Google Scholar 

  53. Fristrom, J. W., and Spieth, Ph., Principles of genetics. Blackwell, Oxford 1980.

    Google Scholar 

  54. Frowein, J., Engel, W., and Weise, H. C., HCG receptor present in the gonadotropin insensitive leydig cell of the immature rat. Nature, New Biol.246 (1973) 141–150.

    Article  Google Scholar 

  55. Ganguli, S., Sirha, M., and Sperling, M. A., Ontogeny of insulin and glucagon receptors and the adenylate cyclase system in guinea pig liver. Pediatr. Res.18 (1984) 558–565.

    Article  CAS  PubMed  Google Scholar 

  56. Ginsberg, B. H., Kahn, C. R., and Roth, J., The insulin receptor of the turkey erythrocyte: similarity to mammalian insulin receptors. Endocrinology100 (1977) 520–525.

    Article  Google Scholar 

  57. Gaspard, K. J., Klitgaard, H. M., and Wondergem, R., Sometomedin and thyroid hormones in the developing chick embryo. Proc. Soc. expl. Biol. Med.166 (1981) 24–27.

    Article  CAS  Google Scholar 

  58. Hollenberg, M. D., Receptor models and the action of neurotransmitters and hormones: some new perspectives, in: Neurotransmitter Receptor Binding. 2nd edn Ed. H. I. Yamamura. Raven Press, New York 1985.

    Google Scholar 

  59. Inczefi-Gonda, Á., Csaba, G., and Dobozy, O., Neonatal insulin treatment and adult receptor binding capacity in rats. Horm. Metab. Res.14 (1982) 211–222.

    Article  Google Scholar 

  60. Inczefi-Gonda, Á., Csaba, G., and Dobozy, O., Effect of neonatal glucocorticoid (triamcinolone) treatment on the myocardial ouabain binding in adult rat. Acta physiol. hung. in press (1985).

  61. Inczefi-Gonda, Á., and Csaba, G., Prolonged influence of a single neonatal steroid (dexamethasone) treatment on thymocytic steroid binding. Expl clin. Endocr.85 (1985) 358–360.

    Article  CAS  Google Scholar 

  62. Inczefi-Gonda, Á., Csaba, G., and Dobozy, O., Reduced thymic glucocorticoid reception in adult rats prenatally treated with allylestrenol. Acta physiol. hung.67 (1986) 27–29.

    CAS  PubMed  Google Scholar 

  63. King, D. B., King, C. R., and Eshleman, J. R., Serum triiodothyronine levels in the embryonic post hatching chicken with particular reference to feeding induced changes. Gen. comp. Endocr.31 (1977) 216–219.

    Article  CAS  PubMed  Google Scholar 

  64. Leder, P., The genetics of antibody diversity. Scient. Am.246 (1982) 72–83.

    Article  Google Scholar 

  65. Maes, M., DeHertogh, R., Watrin-Granger, P., and Keterslegers, J. M., Ontogeny of liver somatotropic and lactogenic binding sites in male and female rats. Endocrinology113 (1983) 1325–1332.

    Article  CAS  PubMed  Google Scholar 

  66. Malini, P. L., Strocki, E., Marata, A. M., and Ambrosini, E., Digitalis ‘receptors’ during chronic digoxin treatment. C. Expl Pharmac. Physiol.11 (1984) 285–289.

    Article  CAS  Google Scholar 

  67. Mess, B., and Strazniczky, K., Differentiation and function of the hypophyseal target organs system in chicken embryos. Hung. Acad. Sci. Budapest 1970.

    Google Scholar 

  68. Muggeo, M., Ginsberg, B. H., Roth, J., Neville, G. M., Meyts, P. de, and Kahn, G. R., The insulin receptor in vertebrates is functionally more conserved during evolution, than the insulin itself. Endocrinology104 (1979) 1393–1402.

    Article  CAS  PubMed  Google Scholar 

  69. Muggeo, M., Obberghen, E. van, Kahn, C. R., Roth, J., Ginsberg, B. H., Meyts, P. de, Emdin, S. O., and Falkmer, S., The insulin receptor and insulin of the atlantic hagfish. Diabetes28 (1979) 175–181.

    Article  CAS  PubMed  Google Scholar 

  70. Myachi, Y., Nieslag, E., and Lipsett, M. B., The secretion of gonadotropin and testosterone by the neonatal male rat. Endocrinology91 (1973) 1–6.

    Article  Google Scholar 

  71. Nagy, S. U., and Csaba, G., Long lasting amplification and deformation of thyroid receptors after thyrotropin (TSH) and gonadotropin (GTH) treatment of chickens in the foetal period. Acta physiol. hung.56 (1980) 303–307.

    CAS  PubMed  Google Scholar 

  72. Nagy, S. U., and Csaba, G., Dose dependence of the thyrotropin (TSH) receptor damaging effect of gonadotropin in the newborn rats. Acta physiol. hung.56 (1980) 417–420.

    CAS  PubMed  Google Scholar 

  73. Rao, C. V., Receptor for gonadotropins in human ovaries, in: Recent Advances in Fertility Research. Part A. pp. 123–135. Alan R. Liss, New York 1982.

    Google Scholar 

  74. Rao, C. V., and Chegini, N., Nuclear receptors for gonadotropins and prostaglandins, in: Evolution of Hormone Receptor Systems. pp. 413–423. Alan R. Liss, New York 1983.

    Google Scholar 

  75. Reichert, L. E., and Bhalla, V. K., Development of a radioligand tissue receptor assay for human follicle stimulating hormone. Endocrinology94 (1974) 483–491.

    Article  CAS  PubMed  Google Scholar 

  76. Rónai, A. Z., Dobozy, O., Berzétei, I., Kurgyis, J., and Csaba, G., The effect of neonatal treatment of mice with opioid and dopaminergic agents on the late responsiveness of vasa deferentia to opioids in vitro. Acta biol. hung.35 (1984) 43–47.

    PubMed  Google Scholar 

  77. Sara, V. R., Hall, K., Misaki, M., Fryklund, L., Christensen, N., and Wetterberg, L., Ontogenesis of somatomedin and insulin receptors in the human fetus. J. clin. Invest.71 (1983) 1084–1094.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Shahin, M. A., Török, O., and Csaba, G., The overlapping effects of thyrotropin and gonadotropin on chick embryo gonads in vitro. Acta morph. hung.30 (1982) 109–125.

    CAS  PubMed  Google Scholar 

  79. Shahin, M. A., Sudár, F., Dobozy, O., and Csaba, G., electronmicroscopic study of the overlapping effect of thyrotropin and gonadotropins on the Leydig cells of 15-day-old chick embryo. Z. mikrosk.-anat. Forsch.98 (1984) 926–938.

    CAS  PubMed  Google Scholar 

  80. Szego, C. M., Parallels in the mode of action of peptide and steroid hormones: membrane effects and cellular entry, in: Structure and Function of gonadotropins, pp. 431–472. Ed. K. W. McKerns. Plenum Press, New York 1978.

    Chapter  Google Scholar 

  81. Szego, C. M., and Pietras, R. J., Lysosome function in cellular activation: propagation of the actions of hormones and other effectors. Int. Rev. Cytd.88 (1984) 1–302.

    Article  CAS  Google Scholar 

  82. Thorsson, A. V., and Hintz, R. L., Insulin receptors in the membrane increased in receptor affinity and number. New Engl. J. Med.297 (1977) 908–912.

    Article  CAS  PubMed  Google Scholar 

  83. Ward, D. M., Correlation of hormonal structure with hormonal function in mammalian tissues, in: Invertebrate Endocrinology and Hormonal Heterophylly. Ed. W. J. Burdette. Springer, Berlin 1974.

    Google Scholar 

  84. Warren, D. W., Huhtaniemi, I. T., Topanainen, J., Dufau, M. L., and Catt, K. J., Ontogeny of gonadotropin receptors in the fetal and neonatal rat testis. Endocrinology114 (1984) 470–476.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Csaba, G. Receptor ontogeny and hormonal imprinting. Experientia 42, 750–759 (1986). https://doi.org/10.1007/BF01941521

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01941521

Key words

Navigation