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Human myeloperoxidase activity is inhibited in vitro by quercetin. Comparison with three related compounds

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Summary

Quercetin is an effective inhibitor of human myeloperoxidase (MPO) activity, both with purified enzyme (IC50=3.5 μM) and in a system using stimulated human neutrophils. Quercetin is significantly more potent than three other related compounds (rutin, rutin sulfate and troxerutin) and than methimazole, a previously-known myeloperoxidase inhibitor. The inhibitory activity of quercetin is of the competitive type. Moreover, quercetin is directly able to scavenge hypochlorous acid (HOCl), a chlorinated species generated by the, MPO/H2O2/Cl− system.

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Authors and Affiliations

  1. Laboratoire de Biochimie et de Radiobiologie, Institut de Chimie B6, Université de Liège 1, rue Dos Fanchon, B-4000, Liège, Belgium

    J. Pincemail, C. Deby, M. de Bruyn-Dister & R. Goutier

  2. Centre de transfusion Sanguine de Liège, rue Dos Fanchon, B-4000, Liège, Belgium

    A. Thirion

Authors
  1. J. Pincemail
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  2. C. Deby
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  3. A. Thirion
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  4. M. de Bruyn-Dister
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  5. R. Goutier
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Pincemail, J., Deby, C., Thirion, A. et al. Human myeloperoxidase activity is inhibited in vitro by quercetin. Comparison with three related compounds. Experientia 44, 450–453 (1988). https://doi.org/10.1007/BF01940544

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  • DOI: https://doi.org/10.1007/BF01940544

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