Summary
The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of Δ1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.
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We thank the National Institute on Drug Abuse for supporting this project by grants DA-02043 and DA-02052 and for supplying all of the cannabinoids. One of us (S.B.) is also the recipient of a Research Scientist Award from NIDA. We are grateful to Kristen Carlson and Thomas Honeyman for helpful suggestions in preparing this report.
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Burstein, S., Hunter, S.A., Latham, V. et al. A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice. Experientia 43, 402–403 (1987). https://doi.org/10.1007/BF01940427
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DOI: https://doi.org/10.1007/BF01940427