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Inactivation of sarin and soman by cyclodextrins in vitro

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Summary

Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for β-cyclodextrin than for α- or γ-cyclodextrins. Thus β-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more effectively. Such a catalyst might contribute to improving the therapy of poisoning caused by these two nerve agents.

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  1. Division de Chimie et Pharmacologie, Centre de Recherches du Service de Santé des Armées, 108 boulevard Pinel, F-69275, Lyon Cedex 03, France

    B. Désiré & S. Saint-André

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  1. B. Désiré
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  2. S. Saint-André
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Désiré, B., Saint-André, S. Inactivation of sarin and soman by cyclodextrins in vitro. Experientia 43, 395–397 (1987). https://doi.org/10.1007/BF01940424

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