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Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis

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Summary

Treatment of reconstituted collagen fibrils and pieces of rat dermis with the crude extract, purified tannins or (+)-catechin from betel nut (Areca catechu) increases their resistance to both human and bacterial collagenases in a concentration-dependent manner. These tanning agents may stabilise collagen in vivo following damage to the oral epithelium and promote the sub-epithelial fibrosis which occurs in betel nut chewers.

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Authors and Affiliations

  1. Department of Oral & Maxillo-Facial Surgery, Institute of Dental Surgery, Eastman Dental Hospital, 256 Gray's Inn Road, WC1X8LD, London, England

    A. Scutt, S. Meghji, J. P. Canniff & W. Harvey

Authors
  1. A. Scutt
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  2. S. Meghji
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  3. J. P. Canniff
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  4. W. Harvey
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Scutt, A., Meghji, S., Canniff, J.P. et al. Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis. Experientia 43, 391–393 (1987). https://doi.org/10.1007/BF01940422

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  • DOI: https://doi.org/10.1007/BF01940422

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