Summary
Contractile responses to acetylcholine were measured using isolated tracheae obtained from actively sensitized guinea pigs 0.5, 1, 5, 20, 24, 48 and 72 h after antigen challenge. Tracheal contractions to acetylcholine and to histamine were significantly increased 20 h but not 0.5, 1, 5, 24, 48 and 72 h after antigen challenge indicating bronchial hyperreactivity. When animals were pretreated with azelastine and then exposed to antigen challenge, concentration-response curve to acetylcholine did not differ from that obtained in control (non-challenged) tracheae. It is likely that azelastine is able to inhibit bronchial hyperresponsiveness to chemical mediators of bronchial asthma.
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Achterrath-Tuckermann, U., Szelenyi, I. Azelastine inhibits bronchial hyperreactivity to acetylcholine in guinea pigs. Experientia 44, 993–996 (1988). https://doi.org/10.1007/BF01939898
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DOI: https://doi.org/10.1007/BF01939898