Abstract
The presence of elastic fibres in the extracellular matrix (ECM) provides physiologically important elastic properties for many tissues. Until recently, microfibrils, one component of the ECM, were thought primarily to serve as a scaffolding on which elastin is deposited during development to form elaunin fibres [1]. The most prominent protein that forms mammalian microfibrils is fibrillin. It is known that mutations in the fibrillin gene cause a heterogenous connective tissue disease called marfan syndrome [2], so information on mechanical properties of microfibrils or their role in tissue function would be useful. Microfibrils are also found in the ECM of some invertebrate tissues, and there is growing evidence that the protein forming the structure is homologous to mammalian fibrillin [3, 4]. It has been shown that the microfibril-based arterial wall of the lobster has viscoelastic properties [5], and we have now utilized this primitive artery to measure the modulus of elasticity of microfibrils. It is similar to that of the rubber-like protein elastin.
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Literatur
Montes G. S. (1992) Distribution of oxytalan, elaunin and elastic fibres in tissues. J. Brazilian, Assoc. Adv. Sci.44: 224–233
Ramirez F. L., Pereira L., Zhang H. and Lee B. (1993) The fibrillin-Marfan syndrome connection. BioEssays15: 589–594
Thurmond F. A., Koob T. J. and Trotter, J. A. (1995) The microfibrils of sea cucumber dermis are similar to fibrilin microfibrils and form a network that has long range elasticity. Molec. Biol. Cell6 (Suppl.): 380a
Ruber-Muller S., Spissinger T., Schuchert P. Spring J. and Schmid V. (1995) An extracellular matrix protein of jellyfish homologous to mammalian fibrillins forms different fibrils depending on the life stage of the animal. Devl Biol.169: 662–672
Davison I. G., Wright G. M. and DeMont M. E. (1995) The structure and physical properties of invertebrate and primitive vertebrate arteries. J. Expl Biol.198: 2185–2196
Keene D. R., Maddox B. K., Kuo H. J., Sakai L. Y. and Glanville R. W. (1991), Extraction of extendable beaded structures and their identification as fibrillin-containing extracellular matrix microfibrils. J. Histochem. Cytochem.39: 441–449
Liu S. Q. and Fung Y. C. (1988) Zero-stress states of arteries. J. Biomed. Eng.110: 82–84
Zar J. H. (1984) Biostatistical Analysis, 2nd ed., Prentice Hall, Englewood Cliffs, NJ
DeMont M. E. and Gosline J. M. (1988) Mechanics of jet propulsion in the hydromedusan jellyfish,Polyorchis penicillatus. I. Mechanical properties of the locomotor structure. J. Exp. Biol.134: 313–332
Aaron B. B. and Gosline J. M. (1981) Elastin as a randomnetwork elastomer: a mechanical and optical analysis of single elastin fibers. Biopolymers20: 1247–1260
Reed B. C. (1989) Linear least-squares fits with errors in both coordinates. Am. J. Physics57: 642–646
Reed B. C. (1992) Linear least-squares fits with errors in both coordinates. II. Comments on parameter variances. Am. J. Physics60: 59–62
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McConnell, C.J., Wright, G.M. & DeMont, M.E. The modulus of elasticity of lobster aorta microfibrils. Experientia 52, 918–921 (1996). https://doi.org/10.1007/BF01938880
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DOI: https://doi.org/10.1007/BF01938880