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Sidedness of the inhibitory effects of diamide on Na and water transport in amphibian skin

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Summary

Diamide, a thiol-oxidizing agent, blocks cAMP-mediated stimulation of Na and water transport when added to the outer solution bathing frog skin. No inhibition was found with diamide in the inner solution. These effects may be due to a perturbation of the thiol-disulfide status of specific components of the outer membrane of the epithelium.

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Authors and Affiliations

  1. Departments of Physiology and Medicine, School of Medicine, University of Geneva, CH-1211, Geneva 4, Switzerland

    A. Grosso & R. C. de Sousa

Authors
  1. A. Grosso
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  2. R. C. de Sousa
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Additional information

This work was supported by grants No. 3.1300.73 and 3.043-0.76 from the Swiss National Science Foundation.

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Grosso, A., de Sousa, R.C. Sidedness of the inhibitory effects of diamide on Na and water transport in amphibian skin. Experientia 34, 593–595 (1978). https://doi.org/10.1007/BF01936978

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  • DOI: https://doi.org/10.1007/BF01936978

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