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Effects of cyclophosphamide on the chemical composition of the glomerular basement membrane and non-collagenous urinary glycoprotein of the rat

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Résumé

La cyclophosphamide est un agent efficace dans le traitement de la néphrose lipoidique et de plusieurs maladies rhumatoides qui attaquent la membrane basale glomérulaire (MBG). Des analyses chimiques ont été effectuées sur la MBG et sur la glycoprotéine urinaire chez des rats traités et non traités. Entre les deux groupes on n'a pas constaté de différence dans la composition des amino-acids, mais de grands changements dans le glucose et le galactose de la MBG et la glycoprotéine urinaire ont été observés chez les rats traités à la cyclophosphamide; cette drogue semble donc capable d'altérer l'intégrité de la MBG.

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Author notes

  1. R. M. McIntosh M.D. (Assistant Professor of Pediatrics)

    Present address: Department of Pediatrics, College of Physicians and Surgeons of Columbia University, 630 W. 168th Street, 10032, New York, N.Y., USA

Authors and Affiliations

  1. Gwynne Hazen Cherry Renal Research Laboratory, University of California, Los Angeles, California, USA

    R. M. McIntosh M.D. (Assistant Professor of Pediatrics), H. Kihara, D. B. Kaufman & C. Kulvinskas

  2. Research Department for Mental Retardation, Pacific State Hospital, Pomona, California, USA

    R. M. McIntosh M.D. (Assistant Professor of Pediatrics), H. Kihara, D. B. Kaufman & C. Kulvinskas

  3. University of California School of Medicine, 90024, Los Angeles, California, USA

    R. M. McIntosh M.D. (Assistant Professor of Pediatrics)

  4. College of Physicians and Surgeons of Columbia University, Room 474, William Black Research Building, 10032, New York, New York, USA

    R. M. McIntosh M.D. (Assistant Professor of Pediatrics)

Authors
  1. R. M. McIntosh M.D.
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  2. H. Kihara
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  3. D. B. Kaufman
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  4. C. Kulvinskas
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McIntosh, R.M., Kihara, H., Kaufman, D.B. et al. Effects of cyclophosphamide on the chemical composition of the glomerular basement membrane and non-collagenous urinary glycoprotein of the rat. Experientia 28, 132–133 (1972). https://doi.org/10.1007/BF01935711

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  • DOI: https://doi.org/10.1007/BF01935711

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