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Morphine suppression of ethanol withdrawal in mice

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Summary

The acute administration of morphine, alcohol or dopamine results in a pronounced suppression of the convulsions produced by alcohol in mice. The suppressive action of morphine on alcohol withdrawal in the mouse apparently is not a product of morphine intoxication, but rather to some other specific interaction between alcohol and morphine in the central nervous system. The conclusion suggest that dopamine may play a significant role as a modulator in convulsions produced during alcohol withdrawal.

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Authors and Affiliations

  1. Division of Drug and Alcohol Abuse, Departments of Pharmacology and Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, 78284, San Antonio, Texas, USA

    K. Blum, J. E. Wallace, H. A. Schwerter & J. D. Eubanks

Authors
  1. K. Blum
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  2. J. E. Wallace
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  3. H. A. Schwerter
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  4. J. D. Eubanks
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Additional information

Dr.Kenneth Blum is Associate Professor in Pharmacology at The University of Texas Health Science Center at San Antonio and a Career Teacher in Drug Abuse and Alcoholism under a grant number 1-TO1-DA00290-01 from the National Institute on Drug Abuse.

Acknowledgments. Our thanks are due toB. Wiggins, R. Marin andS. Elston for their excellent technical assistance. Research funded in part by Air Force Grant No. AFOSR-71-2075.

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Blum, K., Wallace, J.E., Schwerter, H.A. et al. Morphine suppression of ethanol withdrawal in mice. Experientia 32, 79–82 (1976). https://doi.org/10.1007/BF01932634

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