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Vitamin D receptors in heart: Effects on atrial natiuretic factor

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Abstract

We report that receptors for vitamin D exist in distinct regions of the heart in female and male mice, predominantly in the right atrium where most of the cardial atrial natriuretic peptide (ANF) is produced. Tritiated 1,25-dihydroxyvitamin D3 (1,25-D3, vitamin D, soltriol) and ANF are colocalized in nuclei and cytoplasm respectively in identical cardiomyocytes. Changes of ANF tissue and blood levels under dietary deficiency and treatment with 1,25-D3 suggest direct genomic actions of vitamin D on myoendocrine cells of the atrium for the regulation of ANF manufacture and secretion. These results were obtained by combining thaw-mount autoradiography with immunocytochemistry using tritiated 1,25-D3 and an antibody against rat ANF. This antibody was also used in a radioimmunoassay to determine atrial natriuretic factor in plasma, atria and ventricles of normal or vitamin D-deficient mice.

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Authors and Affiliations

  1. Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 534 Taylor Hall, 27 599-7090, Chapel Hill, North Carolina, USA

    H. -J. Bidmon & R. Murakami

  2. Clinical Research Institute, H2W 1R7, Montreal, Quebec, Canada

    J. Gutkowska & W. E. Stumpf

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  1. H. -J. Bidmon
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  2. J. Gutkowska
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  3. R. Murakami
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  4. W. E. Stumpf
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Bidmon, H.J., Gutkowska, J., Murakami, R. et al. Vitamin D receptors in heart: Effects on atrial natiuretic factor. Experientia 47, 958–962 (1991). https://doi.org/10.1007/BF01929891

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  • DOI: https://doi.org/10.1007/BF01929891

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