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Myocardial inactivity of therapeutic concentrations of hydralazine and diazoxide

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Zusammenfassung

Therapeutische Konzentrationen von Hydralazin (10−7–2×10−6 M) und von Diazoxid (5×10−6–4×10−5 M) haben keine inotropischen oder chronotropischen Wirkungen auf isolierte Herzmuskeln von Katzen und Meerschweinchen. Hydralazin Konzentrationen über 10−4 M erhöhen die Spannungsentwicklung durch Freisetzung von endogenem Noradrenalin aber vermindern die Schrittmacherfunktion.

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Authors and Affiliations

  1. Hypertension and Clinical Pharmacology Unit, Massachusetts General Hospital, Fruit Street, 02114, Boston, Mass, USA

    J. Koch-Weser

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  1. J. Koch-Weser
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Supported in part by grant No. 3P17HL14150 SCR from the National Institutes of Health.

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Koch-Weser, J. Myocardial inactivity of therapeutic concentrations of hydralazine and diazoxide. Experientia 30, 170–171 (1974). https://doi.org/10.1007/BF01927714

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