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On the metabolism of prostaglandins by rat brain homogenate

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  • Chimica, Biochimica
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Summary

Using radio-immuno assays for prostaglandins and prostaglandin metabolites, three prostaglandin metabolizing enzymes were found in the 100,000×g supernatant of rat brain, 15-hydroxy-prostaglandin-dehydrogenase,Δ 13 and prostaglandin E-9-keto-reductase. Specific activity of the latter enzyme was highest in striatum and midbrain and lowest in cortex, cerebellum and spinal cord.

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Authors and Affiliations

  1. Department of Pharmacology, University of Freiburg i. Br., Katharinenstrasse 29, D-78, Freiburg i. Br., (German Federal Republic, BRD)

    E. E. Kröner & B. A. Peskar

Authors
  1. E. E. Kröner
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  2. B. A. Peskar
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Additional information

This work was supported by the Deutsche Forschungsgemeinschaft (SFB No. 70).

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Kröner, E.E., Peskar, B.A. On the metabolism of prostaglandins by rat brain homogenate. Experientia 32, 1114–1115 (1976). https://doi.org/10.1007/BF01927575

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  • DOI: https://doi.org/10.1007/BF01927575

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