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Alkylating esters VII. The metabolism of iso-propyl methanesulphonate and iso-propyl iodide in the rat

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Zusammenfassung

Nachweis, dass die im Rattenharn auftretenden Metaboliten Isopropyljodid und Isopropylmethansulfonat für einen unterschiedlichen Wirkungsmechanismus der Substanzen in vivo sprechen. Aus Isopropylmethansulfonat entsteht durch einen monomolekularen Prozess das äusserst reactive Dimethylcarboniumion, während Isopropyljodid aufgrund einer bimolekularen Reaktion haupsächlich durch Hydrolyse entgiftet wird.

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Authors and Affiliations

  1. Pharmacology Department, The University, M 13 9PT., Manchester, England

    A. R. Jones & K. Edwards

  2. Paterson Laboratories, Christie Hospital, M20 9BX, Manchester, England

    A. R. Jones & K. Edwards

Authors
  1. A. R. Jones
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  2. K. Edwards
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Jones, A.R., Edwards, K. Alkylating esters VII. The metabolism of iso-propyl methanesulphonate and iso-propyl iodide in the rat. Experientia 29, 538–539 (1973). https://doi.org/10.1007/BF01926650

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