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3,4-Dihydroxyphenylacetic acid (DOPAC): a possible endogenous inhibitor of indoleamine-N-methylation in the rat brain

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Résumé

L'acide dihydroxyphénylacétique (DOPAC) et l'acide homovanillique (HVA) inhibent la méthylation de la tryptamine par une méthylase partiellement purifiée du cerveau de rat. Les concentrations nécessaires à cette inhibition sont hautes et du même ordre de grandeur que celles qu'on peut attendre du métabolisme de la dopamine au niveau des terminaisons dopaminergiques. La chlorpromazine et la clozapine n'influencent pas cette activité enzymatique.

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Authors and Affiliations

  1. Research Department, Pharmaceuticals Division, Ciba-Geigy Ltd., CH-4002, Basel, Switzerland

    P. C. Waldmeier & L. Maitre

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  1. P. C. Waldmeier
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  2. L. Maitre
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Waldmeier, P.C., Maitre, L. 3,4-Dihydroxyphenylacetic acid (DOPAC): a possible endogenous inhibitor of indoleamine-N-methylation in the rat brain. Experientia 30, 456–458 (1974). https://doi.org/10.1007/BF01926289

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