Summary
Effect of internal colchicine on asymmetrical displacement currents was studied by internally perfusing squid giant axons with a solution containing colchicine. It was found that (1) asymmetrical displacement currents were composed of two parts; colchicine-sensitive and colchicine-resistant; that (2) the colchicine-sensitive part had a definite rising phase while the colchicine-resistant one showed an instantaneous jump, followed by exponential decay; and that (3) the colchicine-sensitive part related to normal Na channels.
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Matsumoto, G., Ichikawa, M. & Tasaki, A. Axonal microtubules necessary for generation of sodium current in squid giant axons: II. Effect of colchicine upon asymmetrical displacement current. J. Membrain Biol. 77, 93–99 (1983). https://doi.org/10.1007/BF01925859
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DOI: https://doi.org/10.1007/BF01925859