Abstract
The effect of rat amylin on gastric emptying and intestinal transit in the rat was examined. Amylin administered intracerebroventricularly (1, 2, 2.5 or 4 μg/rat) produced the maximal decrease in gastric emptying and intestinal transit at the dose of 2.5 μg/rat. Higher doses produced a lower effect. Peripheral administration (25, 50 or 100 μg/kg) produced dose-dependent effects. Pre-treatment with neostigmine blocked the effect of amylin when it was centrally injected, while the effect of amylin given peripherally was partially reduced. Pre-treatment with domperidone decreased the inhibitory effect of peripherally injected amylin, but no effect was observed when the peptide was centrally injected.
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clementi, G., Caruso, A., Cutuli, V.M.C. et al. Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat. Experientia 52, 677–679 (1996). https://doi.org/10.1007/BF01925572
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DOI: https://doi.org/10.1007/BF01925572