Zusammenfassung
Das ausStreptomyces hygroscopicus isolierte neue Makrolid Maridomycin II lässt sich mit Säure Mycarcose und Mycaminose spalten. Auf Grund der Oxidation ins Carbomycin sowie der spektroskopischen Daten wurde die Struktur als II erklärt.
Literatur
Detailed microbiological and isolation studies will be published in J. Antibiotics (Tokyo).
MW, molecular weight; VPO, vapour pressure osmometry in ethyl acetate; MS, mass spectrum; MIC, minimum inhibitory concentration againstStaphylococcus aureus (mcg/ml); NMR, nuclear magnetic resonance spectrum in CDCl3 (σ (ppm)); IR, infrared spectrum (KBr, cm−1); UV, ultraviolet spectrum; TLC, thin layer chromatography (SiO2).
s=singlet,d=doublet;dd=double doublet;t=triplet;q=quartet;oct=octet;m=multiplet; J=coupling constant.
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The authors are greatly indebted to Dr.F. A. Hochstein of Chas Phizer & Co., Inc., for valuable gifts of carbomycin and carbomycin B.
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Muroi, M., Izawa, M., Ono, H. et al. Isolation of maridomycins and structure of maridomycin II. Experientia 28, 878–880 (1972). https://doi.org/10.1007/BF01924916
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DOI: https://doi.org/10.1007/BF01924916