Summary
A new strategy for peptide synthesis on polymeric supports is described. This alternating liquid-solid phase peptide synthesis procedure facilitates the ready separation of reacted and unreacted amino component at the end of each coupling reaction. Incomplete coupling reactions and incomplete deprotection reactions, the most serious problems in previously described methods of peptide synthesis on polymeric supports, have in this procedure no influence on the success of a synthesis. The principle is exemplified by the synthesis of the pentapeptide Gly-Val-Gly-Ala-Pro.
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Frank, H., Hagenmaier, H. Eine neues Verfahren zur Peptidsynthese: die alternierende Fest-Flüssigphasen Methode. Experientia 31, 131–133 (1975). https://doi.org/10.1007/BF01924720
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DOI: https://doi.org/10.1007/BF01924720