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Production of duodenal ulcers in the rat by administration of digitoxin

  • Pharmacologica
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Résumé

L'administration i.p. de digitoxine (0,75 mg) à des rats femelles de 220 g produit en 3 à 4 jours un ulcère duodénal chez 50% des animaux. L'estomac reste intact. Les rats mâles sont presque totalement réfractaires. La digitoxine distent aussi l'estomac par rétention alimentaire. La pathogénie de l'ulcère duodénal par la digitoxine reste inexpliquée.

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Authors and Affiliations

  1. Experimental Biology, The Upjohn Comapny, 49002, Kalamazoo, Michigan, USA

    A. Robert, J. E. Nezamis, C. Lancaster & J. N. Badalamenti

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  1. A. Robert
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  2. J. E. Nezamis
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  3. C. Lancaster
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  4. J. N. Badalamenti
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Robert, A., Nezamis, J.E., Lancaster, C. et al. Production of duodenal ulcers in the rat by administration of digitoxin. Experientia 30, 781–783 (1974). https://doi.org/10.1007/BF01924184

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  • DOI: https://doi.org/10.1007/BF01924184

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