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Ligand-leakage in affinity chromatography, a mathematical approach

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Zusammenfassung

Es wird ein theoretisches Modell beschrieben für die Abspaltung polyvalent gebundener Liganden von einem, wasserunlöslichen Träger. Die Annahme einer konsekutiven Reaktion führt zu einer Abschätzung der zu erwartenden Zeitverzögerung.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Sciences, Catholic University, Toernooiveld, Nijmegen, The Netherlands

    T. C. J. Gribnau & G. I. Tesser

Authors
  1. T. C. J. Gribnau
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  2. G. I. Tesser
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Additional information

Acknowledgment. The authors are indebted to Dr.B. Th. Berrendts for the graphic solution of equation (3), and toIr. J. L. Hendrikse and Dr.Ir. J. H. Kaspersma for their ready cooperation in writing the computer program.

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Gribnau, T.C.J., Tesser, G.I. Ligand-leakage in affinity chromatography, a mathematical approach. Experientia 30, 1228–1230 (1974). https://doi.org/10.1007/BF01923707

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