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Aromatization of androgens to estrogens by the rat pineal gland

  • Endocrinologica
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Résumé

Des homogénats de glande pineale de rat mâle métabolisèrent de la testostérone-C14 in vitro en œstradiol-C14 et en œstrone-C14. Les métabolites furent identifiés chiomatographiquement et dans le cas de l'œstradiol par recristallisation à activité spécifique constante. La conversion de la testostérone en œstradiol fut de 0.19–0.27% et en œstrone de 0.02–0.04%. Ces résultatsci indiquent que la pinéale ressemble à d'autres régions du cerveau soumises au contrôle de la sécrétion de gonadotropines.

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Authors and Affiliations

  1. Instituto Latinoamericano de Fisiología de la Reproducción (ILAFIR), Casilla de Correo 10, S. Miguel, P.B.A., Argentina

    D. P. Cardinali, C. A. Nagle & J. M. Rosner

Authors
  1. D. P. Cardinali
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  2. C. A. Nagle
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  3. J. M. Rosner
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Additional information

These studies were supported by grants from the Comisión Nacional de Estudios Geo-Heliofísicos, Argentina and the World Health Organization. D.P.C. and C.A.N. are established investigators of the Comisión Nacional de Estudios Geo-Heliofísicos. J.M.R. is an established investigator of the Consejo Nacional de Investigaciones Cientificas y Técnicas, Argentina.

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Cardinali, D.P., Nagle, C.A. & Rosner, J.M. Aromatization of androgens to estrogens by the rat pineal gland. Experientia 30, 1222–1223 (1974). https://doi.org/10.1007/BF01923703

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  • DOI: https://doi.org/10.1007/BF01923703

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