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Proopiomelanocortin expression in the skin during induced hair growth in mice

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Abstract

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30–33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.

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Authors and Affiliations

  1. Department of Immunology and Microbiology, Albany Medical College, 12202, Albany, New York, USA

    A. Slominski

  2. Department of Anatomy, Cell Biology and Neurobiology, Albany Medical College, 12202, Albany, New York, USA

    R. Paus

  3. Department of Dermatology, University Hospital R. Virchow, Freie Universität Berlin, D-1, Berlin 65, Germany

    J. Mazurkiewicz

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  1. A. Slominski
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  2. R. Paus
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  3. J. Mazurkiewicz
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Slominski, A., Paus, R. & Mazurkiewicz, J. Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia 48, 50–54 (1992). https://doi.org/10.1007/BF01923606

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  • DOI: https://doi.org/10.1007/BF01923606

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