Skip to main content
SpringerLink
Log in

Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and‡ 9-THC using the micronucleus test

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Using the micronucleus test as a screening method for mutagenic activity, no significant increase in the number of micronuclei was found when LSD, psilocybin or Δ9-THC were administered in 3 logarithmically increasing doses to mice. Azathioprine (Imuran®), given as a positive control, caused a statistically significant increase in micronucleated cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. T. M. Schroeder, in: Chemical Mutagenesis in Mammals and Man, p. 214. Ed. F. Vogel and G. Röhrborn. Springer Verlag, Berlin 1970.

    Google Scholar 

  2. K. Boller and W. Schmid, Hum. Genet.11, 35 (1970).

    Article  Google Scholar 

  3. W. Schmid, in: Chemical Mutagens, vol. 4, p. 31. Plenum Publ. Corp., New York 1976.

    Google Scholar 

  4. R. J. Šrám, Z. Zudová and P. Goetz, Mutat. Res.26, 517 (1974).

    PubMed  Google Scholar 

  5. R. J. Šrám and P. Goetz, Mutat. Res.26, 523 (1974).

    PubMed  Google Scholar 

  6. P. Goetz, R. J. Šrám and Z. Zudová, Mutat. Res.26, 513 (1974).

    PubMed  Google Scholar 

  7. L. F. Jarvik, F. S. Yen, C. C. Dahlberg, J. L. Fleiss, J. Jaffe, T. Kato and E. Moralishvili, Dis. nerv. Syst.35, 399 (1974).

    Google Scholar 

  8. Fernandez, I. W. Browne, J. Cullen, T. Cullen, T. Brennan, H. Matheu, I. Fischer, J. Masterson and E. Law, Ann. hum. Genet.37, 81 (1973).

    PubMed  Google Scholar 

  9. M. T. Nicholson, H. B. Pace and W. M. Davis, Res. Commun. chem. Path. Pharmac.6, 427 (1973).

    Google Scholar 

  10. H. Marquez-Monter, E. Ruiz-Ramirez and J. Carranza-Acevedo,Patología 13, 276 (1975).

    Google Scholar 

  11. P. Eberle and H. Leuner, Hum. Genet.,9, 281 (1970).

    Google Scholar 

  12. R. L. Neu, H. O. Powers, S. King and L. I. Gardner. J. clin. Pharmac.10, 228 (1970).

    Google Scholar 

  13. M. A. Stenchever and M. Allen, Am. J. Obstet. Gynec.114, 819 (1972).

    PubMed  Google Scholar 

  14. W. W. Nichols, R. C. Miller, W. Heneen, C. Bradt, L. Hollister and S. Kanter, Mutat. Res.26, 413 (1974).

    PubMed  Google Scholar 

  15. S. S. Matsuyama, F. S. Yen, L. F. Jarvik, R. S. Sparkes, T. K. Fu, H. Fischer, N. Reccius and I. M. Frank, Mutat. Res.48, 255 (1977).

    PubMed  Google Scholar 

  16. P. A. Martin, M. Thorburn and S. A. Bryant, Teratology9, 81 (1974).

    Article  PubMed  Google Scholar 

  17. M. A. Stenchever, T. J. Kunysz and M. A. Allen, Am. J. Obstet. Gynec.118, 106 (1974).

    PubMed  Google Scholar 

  18. T. H. Maugh, Science185, 683 (1974).

    Google Scholar 

  19. G. F. Van Went, to be published.

Download references

Author information

Authors and Affiliations

  1. Laboratory of Pharmacology, National Institute of Public Health, P.O. Box 1, Bilthoven, (The Netherlands)

    G. F. Van Went

Authors
  1. G. F. Van Went
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgment. The expert technical assistance of Mr Joop Branger is greatfully acknowledged. We thank Prof. Dr C. A. Salemink, University of Utrecht, for the supply of the THC, and Dr J. Fokkens, National Institute of Public Health, for preparing the solutions.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Van Went, G.F. Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and‡ 9-THC using the micronucleus test. Experientia 34, 324–325 (1978). https://doi.org/10.1007/BF01923013

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01923013

Keywords

Search

Navigation