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An adrenergic participation subserving a positive inotropism and chronotropism of prostacyclin on isolated rat atria

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Summary

The effects of prostacyclin (PGI2) on the contractile frequency and on the isometric developed tension of spontaneously beating or paced isolated rat atria were explored. PGI2 enhanced frequency and contractile tension, both effects being blocked by the presence of propranolol, or following a pretreatment with 6-OHDopamine.

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Authors and Affiliations

  1. Centro de Estudios Farmacológicos y de Principios Naturales, Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina, Obligado 2490, 1428, Buenos Aires, Argentina

    L. S. Borda, L. Cangas, M. F. Gimeno & A. L. Gimeno

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  1. L. S. Borda
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  2. L. Cangas
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  3. M. F. Gimeno
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  4. A. L. Gimeno
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Additional information

This work has been supported by Grant 6638 from the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina.

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Borda, L.S., Cangas, L., Gimeno, M.F. et al. An adrenergic participation subserving a positive inotropism and chronotropism of prostacyclin on isolated rat atria. Experientia 35, 529–530 (1979). https://doi.org/10.1007/BF01922751

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  • DOI: https://doi.org/10.1007/BF01922751

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