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Mathematical model of pituitary thyrotropic function

  • Endocrinologica
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Summary

A nonlinear differential equation is used to develop a mathematical model describing the time course of thyrotropin (TSH) concentration in human plasma after thyroliberin (TRH) stimulation. The application of the model to real data shows that pituitary responsiveness to TRH is highest in euthyroidism, reduced in primary hypothyroidism, and lowest in hyperthyroidism.

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Authors and Affiliations

  1. Medizinische Poliklinik, University of Tübingen, Liebermeisterstrasse 14, D-7400, Tübingen 1, Federal Republic of Germany

    F. J. Seif

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  1. F. J. Seif
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Seif, F.J. Mathematical model of pituitary thyrotropic function. Experientia 33, 1243–1245 (1977). https://doi.org/10.1007/BF01922356

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  • DOI: https://doi.org/10.1007/BF01922356

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