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Effect of cadmium on polyribosome structure and function in mouse liver

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Summary

Cadmium chloride injected to mice (20 μmoles/kg) provokes in the livers a degradation of polyribosomes and diminishes their protein synthetic ability measured in vitro. CdCl2 added in a final concentrations between 30 and 100 μM to the protein synthetic cell-free system derived from livers of control mice inhibits its activity.

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Author information

Authors and Affiliations

  1. Institute of Pathological Physiology, Medical Faculty, University of Zagreb, Kišpatićeva 12, 41000, Zagreb, Yugoslavia

    S. Gamulin, N. Car & P. Narancsik

Authors
  1. S. Gamulin
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  2. N. Car
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  3. P. Narancsik
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Additional information

Acknowledgments. We are grateful to Prof. P. Sokolić for helpful discussion. The work was supported by Wellcome Trust grant and by a gift of chemicals from Kemika, Zagreb. We are grateful to both these organizations.

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Gamulin, S., Car, N. & Narancsik, P. Effect of cadmium on polyribosome structure and function in mouse liver. Experientia 33, 1144–1145 (1977). https://doi.org/10.1007/BF01922292

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  • DOI: https://doi.org/10.1007/BF01922292

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