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ACCP/SCCM Consensus Conference definitions correlate better with procalcitonin than tumor-necrosis-factor-α and interleukin-6

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Conclusion

In contrary to TNF-α and IL-6, PCT differs in all stages of systemic inflammation proportional to severity in accordance with the consensus conference definitions. PCT values are helpful in newly and severely infected patients, primarily of bacterial cause. After endotoxin injection PCT increases shortly after TNF-α and before IL-6 (1). Hence PCT might serve as an early and dependable indicator in patients suffering from severe infection/systemic inflammation. The results have yet to be confirmed by greater sample sizes.

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ReferencesReference

  1. P. Dandona et al. 1994 Procalcitonin Increases after Endotoxin Injection in Normal Subjects. J Clin Endocrinol Metab 79:1605–1608.

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Authors and Affiliations

  1. Dept. of Anesthesiology and Intensive Care Medicine, Friedrich-Schiller-University, D-07740, Jena

    M. Oberhoffer, D. Bögel, A. Meier-Hellmann & K. Reinhart

  2. Dept. of Clinical Immunology, Friedrich-Schiller-University, D-07740, Jena

    H. Vogelsang

Authors
  1. M. Oberhoffer
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  2. D. Bögel
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  3. A. Meier-Hellmann
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  4. H. Vogelsang
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  5. K. Reinhart
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Oberhoffer, M., Bögel, D., Meier-Hellmann, A. et al. ACCP/SCCM Consensus Conference definitions correlate better with procalcitonin than tumor-necrosis-factor-α and interleukin-6. Intensive Care Med 22 (Suppl 1), S15 (1996). https://doi.org/10.1007/BF01921189

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  • DOI: https://doi.org/10.1007/BF01921189

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