Skip to main content
SpringerLink
Log in

Lack of effect of butylated hydroxytoluene on dimethylhydrazine-induced colon carcinogenesis in rats

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Rats were given 6600 ppm of butylated hydroxytoluene (BHT) in the diet along with 10 weekly oral doses of dimethylhydrazine (DMH, 30 mg/kg). The incidence and mean number of colonic tumors produced were similar to that of rats given DMH alone. Thus, BHT did not provide any protective effect against colon carcinogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L.W. Wattenberg, J. nat. Cancer Inst.48, 1425 (1972).

    CAS  PubMed  Google Scholar 

  2. T.J. Slaga and W.M. Bracken, Cancer Res.37, 1631 (1977).

    CAS  PubMed  Google Scholar 

  3. J.L. Speier, L.K.T. Lam and L.W. Wattenberg, J. nat. Cancer Inst.60, 605 (1978).

    Article  CAS  PubMed  Google Scholar 

  4. B.M. Ulland, J.H. Weisburger, R.S. Yamamoto and E.K. Weisburger, Fd Cosmet. Toxic.11, 199 (1973).

    Article  CAS  Google Scholar 

  5. L.W. Wattenberg, J. nat. Cancer Inst.54, 1005 (1975).

    Article  CAS  PubMed  Google Scholar 

  6. E.K. Weisburger, R.P. Evarts and M.L. Wenk, Fd Cosmet. Toxic.15, 139 (1977).

    Article  CAS  Google Scholar 

  7. D. Gilbert and L. Golberg, Fd Cosmet. Toxic.3, 417 (1965).

    Article  CAS  Google Scholar 

  8. D. Gilbert, A.D. Martin, S.D. Gangolli, R. Abraham and L. Goldberg, Fd Cosmet. Toxic.7, 603 (1969).

    Article  CAS  Google Scholar 

  9. T.A. Barbolt and R. Abraham, Proc. Soc. exp. Biol. Med.157, 654 (1978).

    Article  Google Scholar 

  10. R. Abraham and T.A. Barbolt, Cancer Res.38, 2763 (1978).

    CAS  PubMed  Google Scholar 

  11. J.M. Ward, Lab. Invest.30, 505 (1974).

    CAS  PubMed  Google Scholar 

  12. P.H. Grantham, J.H. Weisburger and E.K. Weisburger, Fd Cosmet. Toxic.11, 209 (1973).

    Article  CAS  Google Scholar 

  13. E.S. Fiala, Cancer36, 2407 (1975).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center of Experimental Pathology and Toxicology, Albany Medical College, 12208, Albany, New York, USA

    T. A. Barbolt & R. Araham

Authors
  1. T. A. Barbolt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Araham
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported in part by NIEHS Research Grant No. 2-PO1-ES00226-10, NIH Training Grant No. IT32-ES07058-DI, and Dr Abraham's Research Career Development Award No. 1-KO4-ES70608-05. We appreciate the excellent technical assistance given by S. Khilnani and N. Ringwood and the help given by M.T. Corey in preparing the manuscript.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barbolt, T.A., Araham, R. Lack of effect of butylated hydroxytoluene on dimethylhydrazine-induced colon carcinogenesis in rats. Experientia 35, 257–258 (1979). https://doi.org/10.1007/BF01920650

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01920650

Keywords

Search

Navigation