Skip to main content
SpringerLink
Log in

Dose-effects of 8-methoxypsoralen and long wave UV-light in 3T3 cells: evaluation of a phototoxic index

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

3T3 cells were cultured until confluency and treated with various doses of 8-methoxypsoralen followed by long wave UV light irradiation. The inhibition of3H-thymidine incorporation was dose-dependent for both, psoralen and light. A phototoxic index (PTI) was established demonstrating that a constant correlation between psoralen and UVA light exists for the photoinactivation in living cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. F. Dall'Acqua, S. Marciani, L. Ciavatta and G. Rodighiero, Z. Naturf.26b, 561 (1971).

    Article  Google Scholar 

  2. R.S. Cole, Biochim. biophys. Acta217, 30 (1970).

    Article  CAS  PubMed  Google Scholar 

  3. R.S. Cole, Biochim. biophys. Acta254, 30 (1971).

    Article  CAS  PubMed  Google Scholar 

  4. F. Dall'Acqua, S. Marciani, D. Vedaldi, G. Rodighiero, Biochim. biophys. Acta353, 267 (1974).

    Article  CAS  PubMed  Google Scholar 

  5. M.A. Pathak and D.M. Krämer, Biochim. biophys. Acta195, 197 (1969).

    Article  CAS  PubMed  Google Scholar 

  6. E. Ben-Hur and M.M. Elkind, Biochim. biophys. Acta331, 181 (1973).

    Article  CAS  PubMed  Google Scholar 

  7. K. Wolff, H. Hönigsmann, F. Gschnait and K. Konrad, Dt. med. Wschr.100, 2471 (1975).

    Article  CAS  Google Scholar 

  8. J.A. Parrish, T.B. Fitzpatrick, L. Tanenbaum and M.A. Pathak, New Engl. J. Med.291, 1207 (1974).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Dermatology, University of Kiel, D-2300, Kiel, Federal Republic of Germany

    J. Pohl & E. Christophers

Authors
  1. J. Pohl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Christophers
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by Deutsche Forschungsgemeinschaft.

We thank Miss Anne Schröder for her skillful assistance.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pohl, J., Christophers, E. Dose-effects of 8-methoxypsoralen and long wave UV-light in 3T3 cells: evaluation of a phototoxic index. Experientia 35, 247–248 (1979). https://doi.org/10.1007/BF01920643

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01920643

Keywords

Search

Navigation