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Phosphotyrosine protein phosphatase and diabetic pregnancy: an association between low molecular weight acid phosphatase and degree of glycemic control

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Abstract

Low molecular weight acid phosphatase encoded by the highly polymorphic locus ACP 1 is a member of the protein-tyrosin phosphatase family (PTPases) which plays an essential role in the control of receptor signalling through phosphotyrosine pathways. Recent experiments have shown that purified rat liver ACP, corresponding to human ACP1, is able to hydrolyze a phosphotyrosine-containing synthetic peptide corresponding to the 1146–1158 sequence of the human insulin receptor, and shows a high affinity for it. This prompted us to analyze the degree of glycemic control in relation to ACP1 genetic variability in a sample of 214 diabetic pregnant women including IDDM, NIDDM and gestational diabetes. The ACP1 genotype was also determined in 482 non-diabetic pregnant women. In diabetic women glycemic levels in thelast trimester of pregnancy appear to be significantly associated with the ACP1 genotype, and correlated positively with ACP1 enzymatic activity. The data suggest that quantitative variations of ACP1 may influence the clincal mainifestations of diabetic disorders, and call for further studies on the role of this enzyme in the modulation of insulin-receptor phosphotyrosine pathways.

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Authors and Affiliations

  1. Chair of Human Development, University of Rome-Torvergata, School of Medicine, Via di Tor Vergata, 135, C.A.P., I-0133, Rome, Italy

    F. Gloria-Bottini, P. Borgiani, A. Amante & E. Bottini

  2. Department of Child Health, 1st University of Rome, School of Medicine, Rome, Italy

    G. Gerlini

  3. Laboratory of Genetics, University of Camerino, School of Science, Camerino, Italy

    N. Lucarini

  4. Department of Pediatrics, USSL Penne, Stanza 852, Via Orazio Raimondo, I-00173, Rome, Italy

    M. La Torre

  5. Center of Diabetology, USSL, Penne, Italy

    E. Antonacci

Authors
  1. F. Gloria-Bottini
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  2. G. Gerlini
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  3. N. Lucarini
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  4. P. Borgiani
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  5. A. Amante
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  6. M. La Torre
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  7. E. Antonacci
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  8. E. Bottini
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Gloria-Bottini, F., Gerlini, G., Lucarini, N. et al. Phosphotyrosine protein phosphatase and diabetic pregnancy: an association between low molecular weight acid phosphatase and degree of glycemic control. Experientia 52, 340–343 (1996). https://doi.org/10.1007/BF01919537

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  • DOI: https://doi.org/10.1007/BF01919537

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