Abstract
A population of uterine natural killer (NK) cells, commonly called granulated metrial gland (GMG) cells, differentiates in the mouse uterus during normal pregnancy. Little is known regarding the process of differentiation of GMG cells or of other NK cell subsets. It has been suggested that macrophage precursors, under the combined influences of the cytokine growth factors colony stimulating factor-1 (CSF-1) and interleukin-2, become NK-cell like in morphology, pattern of target cell lysis and surface antigen phenotype. Mice expressing the mutation osteopetrosis (op/op) are unable to produce the cytokine CSF-1. To determine whether CSF-1 is required for the successful differentiation of uterine NK cells, implantation sites in pregnant,op/op mice were studied histologically. GMG cell differentiation appeared to progress normally inop/op mice studied between days 7 and 14 of gestation. Thus, the growth factor CSF-1 is not required for differentiation of the uterine NK cell subset known as GMG cells and probably GMG cells do not differentiate from macrophage precursor cells which are deficient inop/op mice.
Similar content being viewed by others
References
Peel, S., Adv. Anat. Cell Biol.115 (1989) 1.
Parr, E. L., Parr, M. B., Zheng, L. M., and Young, J. D.-E., Biol. Reprod.44 (1991) 834.
Kiso, Y., Yamashiro, S., McBey, B.-A., and Croy, B. A., Transplantation54 (1992) in press.
Stewart, I., and Peel, S., Anat. Embryol.160 (1980) 227.
Stewart, I., and Peel, S., Cell Tiss. Res.187 (1978) 167.
Mukhtar, D. D. Y., and Stewart, I. J., Cell Tiss. Res.253 (1988) 413.
Peel, S., Stewart I. J., and Bulmer, D., Cell Tiss. Res.233 (1983) 647.
Mukhtar, D. D. Y., Stewart, I. J., and Croy, B. A., J. Reprod. Immun.15 (1989) 269.
Parr, E. L., Young, L. H. Y., Parr, M. B., and Young, J. D.-E., J. Immun.145 (1990) 365.
Daki, N. M., Stewart, I. J., and Wild, A. E., J. Reprod. Immun.16 (1989) 249.
Parr, E. L., Parr, M. B., and Young J. D.-E., Biol. Reprod.37 (1987) 1327.
Croy, B. A., Reed, N., Malashenko, B.-A., and Kwon, B. S., Cell Immun.113 (1991) 116.
Croy, B. A., and Kiso, Y., Microsc. Res. Tech. (1992) in press.
Linnemeyer, P. A., and Pollack, S. B., J. Immun.147 (1991) 2530.
Trinchieri, G., Adv. Immun.47 (1989) 187.
Karre, K., Hansson, M., and Kiessling, R., Immunology Today12 (1991) 343.
Li, H., Kniep, E., Emmendorffer, A., and Lohmann-Matthes, M.-L., Scand. J. Immun.33 (1991) 511.
Lohmann-Matthes, M.-L., Emmendorffer, A., and Li, H., Pathobiology59 (1991) 117.
Wiktor-Jedrzejczak, W., Ahmed, A., Szczylik, C., and Skelly, R. R., J. exp. Med.156 (1982) 1516.
Wiktor-Jedrzejczak, W., Bartocci, A., Ferrante, A. W. Jr, Ahmed-Ansari, A., Sell, K. W., Pollard, J. W., and Stanley, E. R., Proc. natl Acad. Sci. USA87 (1990) 4828.
Felix, R., Hofstetter, W., Stutzer, A., and Fleisch, H., Calcif. Tissue int., Suppl.42 (1988) 17 (abstr.).
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogowa, M., Nishikawah, H., Sudo, T., Shultz, L. D., and Nishikawa, S.-I., Nature345 (1990) 442.
Pollard, J. W., Hunt, J. S., Wiktor-Jedrzejczak, W., and Stanley, E. R., Dev. Biol.148, (1991) 273.
Croy, B. A., Chapeau, C., Reed, N. Stewart, I. J., and Peel, S., in: Molecular and Cellular Biology of the Fetomaternal Interface, p. 168. Eds T. G. Wegmann, T. Gill and E. Nisbet-Brown. Oxford University Press, 1991.
Wang, J. M., Griffin, J. D., Rambaldi, A., Chen, Z. G., and Mantovani, A., J. Immun.141 (1988) 575.
Robertson, S. A., and Seamark, R. F., Reprod. Fertil. Develop.2 (1990) 359.
Di Persio, J., Billing, P., Kaufman, S., Eghtesady, P., Williams, R. E., and Gasson, J. C., J. biol. Chem.263 (1988) 1834.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kiso, Y., Pollard, J.W. & Croy, B.A. A study of granulated metrial gland cell differentiation in pregnant, macrophage-deficient, osteopetrotic (op/op) mice. Experientia 48, 973–975 (1992). https://doi.org/10.1007/BF01919144
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01919144